ABSTRACT
<p><b>OBJECTIVE</b>To probe the risk of colorectal polyp, colon and rectal carcinoma and the intake of NSAIDs.</p><p><b>METHODS</b>Case-control study participants were from patients who underwent colonoscopy at different hospitals, the persons with the above disease was as cases, and those without the above diseases was as controls. Use of NSAIDs was assessed by interviewing the participants with a questionnaire which include a list of NSAIDs and related dietary and life style factors and family history.</p><p><b>RESULTS</b>There are 37 cases of colorectal polyp, 105 cases of colon carcinoma and 142 cases of rectal carcinoma and 66 controls. Adjusted for potential confounders, the risk of colorectal polyposis, colon carcinoma and rectal carcinoma were markedly reduced by NSAIDs. The OR values were 0.21 (95% CI 0.07-0.65, P = 0.007), 0.13 (95% CI 0.05-0.35, P < 0.001), 0.15 (95% CI 0.11-0.58, P < 0.001) respectively. The risk of the above diseases were also reduced markedly by aspirin, the OR values were 0.265 (95% CI 0.07-0.96, P = 0.044), 0.10 (95% CI 0.03-0.35, P < 0.001), 0.15 (95% CI 0.04-0.49, P = 0.002) respectively. The risk of colon carcinoma was also reduced by profen, with the OR being 0.11 (95% CI 0.02-0.64, P = 0.014).</p><p><b>CONCLUSIONS</b>Aspirin and other NSAIDs could reduced the risk of colorectal polyp, colon carcinoma and rectal carcinoma markedly. Aspirin was the most prospective chemopreventive agents for colorectal polyp, colon and rectal carcinoma for its capability of reducing the risk of cardio-cerebral vascular disease as well.</p>
Subject(s)
Adult , Female , Humans , Male , Middle Aged , Anti-Inflammatory Agents, Non-Steroidal , Therapeutic Uses , Aspirin , Therapeutic Uses , Colorectal Neoplasms , Ibuprofen , Therapeutic Uses , Logistic Models , Piroxicam , Therapeutic Uses , Polyps , Rectal Neoplasms , Risk Factors , Sulindac , Therapeutic Uses , Time FactorsABSTRACT
Objective To study the effect of vanadium on antioxidase activity in liver microsome and mitochondrion of rats. Methods 40 Wistar rats were randomly divided into 7 groups, 6 experimental groups, 1 control group. The rats in experimental groups were treated with ammonium metavanadate through drinking water at the doses of 1.25, 2.5, 5, 10, 20 and 40 mg/kg respectively for 20 consecutive days. The rats in control group were treated with distilled water. GSH-Px, CAT activity in liver microsome and SOD activity, MDA content in liver mitochondrion were determined. Results GSH-Px, CAT, SOD activity decreased and MDA content increased as ammonium metavanadate dosage increased. Compared with the control group, GSH-Px and CAT activity in 5, 10, 20 and 40 mg/kg groups decreased significantly(P