ABSTRACT
Objective: To compare the efficacy of tacrolimus plus narrowband ultraviolet B [NB-UVB] phototherapy versus NB-UVB phototherapy alone in the treatment of vitiligo
Methods: A total of 94 patients were randomized into two equal groups A and B. Patients in group A were managed with combined treatment i.e. NB-UVB three times a week plus topical tacrolimus 0.1% once daily application while patients in group B will be subjected to NB-UVB alone three times a week alone for three months. The efficacy was determined in term of repigmentation by measuring vitiligo area severity score
Results: 41 [87.2%] patients in group A achieved efficacy while group B showed efficacy in 32 [68.1%] patients [p=0.022]. Efficacy was unrelated to age, sex, severity and duration of vitiligo
Conclusion: Combination therapy is more effective than monotherapy in the treatment of vitiligo