Clinics in diagnostic imaging (142). Cervical oesophagus impacted partial denture

A 58-year-old man presented to the emergency department with sudden pain and odynophagia after drinking water. The patient thought that part of his lower denture may have fallen into his throat. There was moderate tenderness over the lower anterior neck. Radiographs of the neck were normal. Computed tomography showed an impacted partial denture in the upper oesophagus, which was removed by rigid endoscopy. Recheck endoscopy showed a superficial mucosal laceration at 18 cm. Ingestion of dental prostheses is common among the elderly population. The role of imaging in the early detection of ingested foreign bodies, particularly nonradio-opaque ones, is discussed.

Exploring the Potential of Flunarizine for Cisplatin-Induced Painful Uremic Neuropathy in Rats / 대한배뇨장애요실금학회지

PURPOSE: The present study was designed to explore the potential of flunarizine for cisplatin induced painful uremic neuropathy in rats. METHODS: Cisplatin (2 mg/kg; i.p., for 5 consecutive days) was administered and renal uremic markers i.e., serum creatinine were estimated on days 4 and 25. Behavioral changes were assessed in terms of thermal hyperalgesia (hot plate, plantar, tail immersion, and tail flick tests at different time intervals). Biochemical analysis of total calcium, superoxide anion, DNA, and transketolase, and myeloperoxidase activity in tissue samples was also performed. Furthermore, flunarizine (100, 200, and 300 microM/kg; p.o., for 21 consecutive days) was administered to evaluate its potency on uremic neuropathy, and the results were compared with those for the carbamazepine-treated (30 mg/kg; p.o., for 21 consecutive days) groups. RESULTS: Flunarizine attenuated the cisplatin-induced uremic neuropathy, and the degree of behavioral and biochemical changes in serum and tissue samples in a dose dependent manner. The medium and high doses of flunarizine were shown to produce a significant effect on cisplatin induced painful uremic neuropathy. CONCLUSIONS: Our results indicate the potential of flunarizine for anti-oxidative, anti-inflammatory, and neuroprotective actions. Therefore, it may have use as a novel therapeutic agent for the management of painful uremic neuropathy.