ABSTRACT
Objective: is an endemic disease. This study was done to compare the efficacy of intralesional meglumine antimoniate [MA] with combination of 50% trichloroacetic acid [TCA] and intralesional meglumine antimoniate in patients of cutaneous leishmaniasis [CL]
Methods: it was a randomized controlled trial conducted in department of dermatology, Military Hospital, Rawalpindi over six months i.e. 02-08-2016 to 01-02-2017. A total of 210 patients [105 in each group] were taken in this study. Group A received 50% TCA fortnightly with intralesional meglumine antimoniate and group B was treated with intralesional meglumine antimoniate alone
Results: efficacy was observed in 91 [86.7%] patients of group A and in 78 [74.3%] patients of group B [p=0.024]
Conclusion: combination therapy with TCA 50% and intralesional MA accelerated the resolution of CL lesions with significant difference in complete resolution rate in comparison to the patients treated with intralesional MA alone