ABSTRACT
Mantha Sanni (Autism) is a Mukkuttra disease that is imbalance of all the three main fundamental principles of Vatham, Pitham and Kabam. Mantha Sanni is a neuro developmental disorder typically appearing in the first one and half years of life and characterised by impaired social and communication skills.. In the all over the world, the surveillance study identified 1 in 68 children suffering with ASD. In India, the prevalence ratio is 1:46. It is about 4.5 times more common among boys (1:48) than among girls (1:189). The higher prevalence rate was observed in the rural area. Socioeconomic status may be one of the fundamental indicators for ASD in India. Autism spectrum disorder is the world most common disorder in Children. In this study, I have to present 3 case reports of ASD children based on the assessment scale. The main course of treatment are Brami Nei as internal and Varmam as External therapy in the recommended dose as per Siddha pharmacopeia for 3 months. After 3 months, ASD children improve the cognitive skills and eye to eye contact Hyperactivity reduced well. Most of the formulation acting on psyche is ghee based. It is well established that the drugs to have its action on brain should have the capacity to cross the blood brain barrier and for the purpose ghee based Brahmi Nei is recommended for ASD in children. Manipulative therapy like Varma is to enhance the mind calming activity with sound sleep, good eye to eye contact and to reduce anxiety, hyperactivity. All the ingredients in both Internal medicines are herbal. So my attorney has to conclude the Siddha management therapy might be good and safest. It will be definitely efficacy in treating ASD children. Hence, Brami Nei as internal Varmam as External therapy may have a role to curing the ASD children.
ABSTRACT
INTRODUCTION: Acne vulgaris is commonly treated with topical antibacterials. We evaluated lincomycin gel, a new topical formulation for mild to moderate acne. MATERIAL AND METHODS: A multicentric, randomized, double blind, placebo controlled, clinical trial was conducted with lincomycin hydrochloride in 2% gel form in 200 patients with grade II and grade III acne. The severity of acne lesions was noted at baseline and after 4 weeks. RESULTS: About 70% cases in the study group showed a good to excellent response, which was significantly more as compared to 23% in the placebo group. The frequency and severity of adverse reactions in the two groups were similar. CONCLUSION: Lincomycin hydrochloride gel is an effective and safe treatment option for mild to moderate acne vulgaris.
ABSTRACT
Effect of different auxins, namely, 2,4-dichlorophenoxyacetic acid (2,4-D), naphthalene acetic acid (NAA) and indole acetic acid (IAA) and Azospirillum brasilense bioinoculation on the enhancement of polygalacturonase (PG) activity in rice roots during para nodulation and endorhizosphere colonization of Azospirillum was studied under in vitro condition. It was observed that Azospirillum bioinoculation could augment PG activity of rice roots to a lesser extent without any root morphogenesis whereas auxin application together with Azospirillum bioinoculation enhanced PG activity of rice roots to a higher level which resulted in better root morphogenesis (para nodule) and endorhizosphere colonisation of A. brasilense. Among the three auxins tested, 2,4-D, even at lower concentration (0.5 ppm) enhanced the rice root PG activity, root morphogenesis and endorhizosphere colonization of Azospirillum while it was 2.0 ppm with NAA and variable with IAA. It is concluded that there is a positive correlation existing among PG activity, degree of root morphogenesis and endorhizosphere colonization of Azospirillum brasilense in rice roots and the degree of correlation is determined by the chemical composition, concentration and mode of action of the auxin utilised.