ABSTRACT
Liver cirrhosis results from prolonged, widespread but patchy hepato-cellular necrosis due to various reasons. To determine the frequency and severity of hyponatremia in patients with liver cirrhosis. Descriptive case series study. Six months. Liaquat University Hospital Hyderabad. The cirrhotic subjects were assessed for hyponatremia and its severity. The data was analyzed in SPSS 16 and the frequency and percentage was calculated for hyponatremia and statistically p -value = 0.05 was considered as significant. Sixty five percent males and thirty five percent females of liver cirrhosis were studied. The mean age +/- SD of overall cirrhotic subjects was 40.79+/-7.83. The hyponatremia was identified in 72% [51 males and 21 females] patients. The mean +/-SD for Na+ level in overall population was 129.73+/-83.51 while it was 119.92+/-3.61 in hyponatraemic cirrhotic subjects. The sodium level in male and female hyponatraemic cirrhotic patients was 121.73+/-8.63 and 118.92+/-3.31. Dilutional hyponatremia is frequent in patients with liver cirrhosis
Subject(s)
Humans , Female , Male , Child , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Hyponatremia/epidemiology , Sodium/bloodABSTRACT
To determine the frequency and severity of thrombocytopenia in patients with liver cirrhosis. Cross sectional study. 01-03-2013 to 31-08- 2013. Liaquat University Hospital, Hyderabad. The cirrhotic patients were assessed for thrombocytopenia and its severity. The data was analyzed in SPSS version 11.00 and frequency and percentage was computed. The chi-square test was applied and p -value =0.05 was considered as statistically significant. Total one hundred patients were evaluated for thrombocytopenia, 70% males and 30% females. The mean +/- SD for age in cirrhotic subjects was 41.16+/-14.24 whereas the mean +/-SD for age in male and female cirrhotic patients was 42.81+/-10.96 and 40.63+/-9.85. The thrombocytopenia was detected in 68%, of which 43[63.2%] were males and 25[36.8%] were females. Mean+/-SD for platelet in all subjects was 130.85+/-8.33 whereas it was 68.82+/-6.52 in thrombocytopenic cirrhotic patients. Mean+/-SD platelet count in male and female thrombocytopenic patients was 70.94+/-7.42 and 64.72+/-5.84. Out of sixty eight thrombocytopenic cirrhotic subjects 23 had mild thrombocytopenia, 25 had moderate thrombocytopenia and 20 had severe thrombocytopenia while in relation to Child-Pugh class B [p<0.01] predominant. Regarding the duration of the liver cirrhosis, the thrombocytopenia was predominant in patients between 6-12 months. The common presenting feature observed in relation to gender were malaise 21%, fatigue 17, nausea / vomiting 14% and combine feature in 21 cirrhotic patients [p=0.04]. The thrombocytopenia was detected in patients with liver cirrhosis, therefore frequent platelet assessment is one of the most important step to monitor platelet count and reduce severe and life threatening episodes of bleeding
Subject(s)
Humans , Female , Male , Adolescent , Adult , Middle Aged , Aged , Aged, 80 and over , Thrombocytopenia/epidemiology , Cross-Sectional Studies , Platelet Count , Blood PlateletsABSTRACT
To determine the frequency and severity of thrombocytopenia and to evaluate the variation of red cell distribution width [RDW] in patients with acute vivax malaria. Cross sectional descriptive case series study. Six months. Liaquat University Hospital. All the patients with acute vivax malaria were evaluated for thrombocytopenia its severity and RDW. The data was analyzed in SPSS 10 and the frequency and percentage was calculated. Total 126 patients with acute vivax malaria were recruited, of which 88 were males and 38 were females. The mean age +/- SD for male and female subjects was 44.76 +/- 6.83 and 40.83 +/- 7.42. The common features observed were fever 31%, rigor 15% and combined features 14% [p=0.05]. The thrombocytopenia was identified in 86 patients of which 65 were males and 21 were females [p=0.04]. The increased RDW was observed in 75 patients of which 57 were males and 18 were females [p=0.05]. The bleeding was detected in 56 and dyspnea and heart failure was found in 30 thrombocytopenic subjects [p=0.02]. Regarding outcome 82 subjects were recovered while the 04 patients were expired [p=0.05]. Regarding severity of thrombocytopenia majority 48.8% were in moderate category with male predominance [p=0.02]. The thrombocytopenia and increased RDW was observed in patients with acute vivax malaria
ABSTRACT
To determine the serum iron level in Helicobacter pylori infected patients. This cross sectional descriptive study was conducted at Liaquat University Hospital [a tertiary care teaching hospital] Hyderabad from July 2013 to December 2013. All the patients with history of presented with acute abdominal pain, dyspepsia, bloating and epigastric discomfort were evaluated for Helicobacter pylori infection by serology. Thereafter the Helicobacter pylori positive individuals were further evaluated for serum iron level. The data was collected, saved and analyzed in SPSS version 11.00. During six month study period total one hundred patients of H. pylori infection was recruited, of which sixty three [63%] were males and thirty seven were females. Sixty six [66%] patients belonged to urban areas while thirty four [34%] were rural population. The mean age +/- SD for overall population was 37.35 +/- 14.0 where as the mean age +/- SD of male and female population was 38.88 +/- 6.77 and 35.67 +/- 8.87 respectively. The serum iron was low in 68% Helicobacter pylori infected patients, of which 48 were males and 20 were females [p=0.02]. The overall mean +/- SD for serum iron level in study population was 49.17 +/- 37.86 mmol/L whereas the mean +/- SD of serum iron for male and female Helicobacter pylori infected population was 42.69 +/- 34.15 and 60.18 +/- 41.66 [p=0.03]. An association was identified between Helicobacter pylori and iron deficiency