ABSTRACT
The object of this study was to determine the difference of radiation effect in different fractional does and to establish optimal fractionation schedule on the whole-abdominal X-ray irradiation. Total 160 mice were irradiated with 150 KVP, 15 mA orthovoltage x-ray machine and two different fractionation (100 cGy/Fr. and 200 cGy/Fr.) were used. Body weight, hemoglobin and WBC count with differential count were analyzed according to the same amount of total dose, same field size and two different fractionation schedules. The results of this study were summarized s follows: There was no significant difference in body weight and hemoglobin concentration by sex or fractional dose. Leukopenic change was prominent in the 3,000 cGy irradiation group and the proportion of decrease was remarkable in the 200 cGy/Fr. Group than 100 cGy/Fr. Group. Progressive decrease of lymphocyte count and reciprocal increase of neutrophil count were noted as dose increment. The effect of the fractional does on WBC count and proportion of lymphocyte were significant. This suggests that judicious selection of fractional dose may be important in clinical radiotherapeutic practice.
Subject(s)
Animals , Mice , Appointments and Schedules , Body Weight , Lymphocyte Count , Lymphocytes , Neutrophils , Radiation EffectsABSTRACT
Radiation effect on mammals, especially on hematologic changes, has been studied since discovery of x-ay. Various experimental animals were tried for radiobiological studies. 72 hybrid mice with conventional ffaction (5X/week), large abdominal field (2 x3cm, from symphysis pubic to xyphoid process) were used. Body weight was declined gradually by increasing irradiation doses, nadir was about 29.7% in male ; 30.4% in female at 6000 rad irradiation group. Hemoglobin value was nearly normal throughout entire treatment. Significant dropping of WBC count was noted to 40-0% of pretreatment values by only 1000 rad irradiation. Change of differential count was interesting; lymphocyte proportion showed gradual reduction, instead of gradual increasing of segmented neutrophil. Those proportion were reversed after 6000 rad irradiation. Urinary protein tests showed + - +++, showing no correlation with dosage. Application. of our study in clinical combination therapy (radiation + chemotherapy) was discussed.
Subject(s)
Animals , Female , Humans , Male , Mice , Body Weight , Lymphocytes , Mammals , Neutrophils , Radiation EffectsABSTRACT
The mouse is one of the most popular experimental animal which has wide variation of strains, diet, environment, breeding technique, and diurnal cycle. Total 731 mice (male 372, female 359) were used for the standard data of our laboratory. Proper age for experiment were 30 +/- days, body weight were 25 +/- gm(male), 23 +/- gm. (female), minimal diurnal variation showed from 9 A.M. to 12 P.M.
Subject(s)
Animals , Female , Humans , Mice , Aging , Body Weight , Breeding , DietABSTRACT
Even though the mechanism and the nature of radiation induced pneumonitis, esophagitis and gastroenteritis were detailed by many authors, complicated secondary infection is still serious problem, sometimes fatal, even today. We experience a case of multiple pyogenic abscess in subcutaneous tissue of the back and both kidneys which could not differenciate from multiple metastatic sarcoma grossly, and report with review of literatures, lab. findings.