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1.
Clinics in Shoulder and Elbow ; : 22-29, 2018.
Article in English | WPRIM | ID: wpr-739714

ABSTRACT

BACKGROUND: This study is performed to evaluate anchor-related outcomes and complications after arthroscopic rotator cuff repair using 30% β-tricalcium phosphate (β-TCP) with 70% poly lactic-co-glycolic acid (PLGA) biocomposite suture anchors. METHODS: A total of 78 patients (mean age, 61.3 ± 6.9 years) who underwent arthroscopic medium-to-large full-thickness rotator cuff tear repair were enrolled. The technique employed 30% β-TCP with 70% PLGA biocomposite suture anchors at the medial row (38 patients, Healix BRTM anchor [Healix group]; 40 patients, Fixone anchor B [Fixone group]). The radiologic outcomes (including perianchor cyst formation or bone substitution) and anatomical outcomes of the healing failure rate were evaluated using magnetic resonance imaging at least 6 months after surgery, the pain visual analogue scale at 3, 6 months, and final follow-up visit, and American Shoulder and Elbow Surgeons scores at least 1 year postoperatively. Anchor-related complications were also evaluated. RESULTS: The perianchor cyst formation incidence was similar for both groups (60.5%, Healix group; 60.0%, Fixone group; p=0.967), although severe perianchor cyst incidence was slightly lower in the Fixone group (15.0%) than in the Healix group (21.1%). There was no occurrence of anchor absorption and bone substitution. No differences were observed in the healing failure rate (13.2%, Healix group; 15.0%, Fixone group; p=0.815) and functional outcome between groups (all p>0.05). Anchor breakage occurred in 5 patients (2 Healix anchors and 3 Fixone anchors); however, there were no major anchor-related complications in either group. CONCLUSIONS: No differences were observed in the clinical outcomes of the Healix and Fixone groups, neither were there any accompanying major anchor-related complications.


Subject(s)
Humans , Absorption , Elbow , Follow-Up Studies , Incidence , Magnetic Resonance Imaging , Rotator Cuff , Shoulder , Surgeons , Suture Anchors , Sutures , Tears
2.
Korean Journal of Perinatology ; : 248-257, 2010.
Article in Korean | WPRIM | ID: wpr-20899

ABSTRACT

PURPOSE: The increasing incidence and mortality of Methicillin-resistant Staphylococcus aureus (MRSA) colonization or blood-stream infection is an important problem in neonatal intensive care unit (NICU). The aims of this study are to evaluate the effective eradication of MRSA through the aggressive isolation program with or without the use of 2% chlorhexidine-gluconate (CHG) and to investigate significant risk factors of MRSA colonization in NICU. METHODS: This study is a retrospective collected data among 414 neonates admitted to a NICU from June 1, 2007, through October 31, 2009. We divided the groups into 3 periods according to isolation program or the use of 2% CHG. RESULTS: The aggressive isolation program decreased the incidence of MRSA colonization and the additional use of 2% CHG has reduced much more the incidence of MRSA colonization and bacteremia. Days of hospitalization, use of central line, days of using central line, presence of respiratory distress syndrome (RDS) or bronchopulmonary dysplasia (BPD), isolation program, and isolation program + use of CHG were significant factors associated with MRSA colonization or bacteremia in univariate logistic regression analysis. Days of using central line and isolation program + use of CHG were significant after in multivariate logistic regression analysis. CONCLUSION: Hand hygiene, active MRSA surveillance culture, isolation, contact isolation, nursing/doctor cohorts and the use of 2% CHG as skin sterilizer were effective in eradicating to MRSA. The effort of shortening the days of using central line is also necessary.


Subject(s)
Humans , Infant, Newborn , Bacteremia , Bronchopulmonary Dysplasia , Chlorhexidine , Cohort Studies , Colon , Hand Hygiene , Hospitalization , Incidence , Infection Control , Intensive Care, Neonatal , Logistic Models , Methicillin Resistance , Methicillin-Resistant Staphylococcus aureus , Retrospective Studies , Risk Factors , Skin
3.
Korean Journal of Perinatology ; : 266-272, 2010.
Article in Korean | WPRIM | ID: wpr-20897

ABSTRACT

PURPOSE: To study the safety of more aggressive parenteral amino acid supplementation on liver functions during parenteral nutrition in preterm infants. METHODS: Medical records of preterm infants (n=58) treated in the neonatal intensive care unit from 2004 through 2008 with birth weight less than 2,000 g and exposure to parenteral nutrition (PN) for more than 7 days were reviewed. Patients were divided into two groups; low amino acid intake group (LAA, n=32) admitted from January 2004 to May 2006 and high amino acid intake group (HAA, n=26) admitted from June 2006 to July 2008. The incidence of cholestasis was compared between the two groups and the liver functions in infants with cholestasis were evaluated. RESULTS: Mean protein intake was significantly higher in HAA (1.0+/-0.2 g/kg/day vs 2.1+/-0.6 g/kg/day, P=0.001). But there were no differences in the incidence and duration of cholestasis between the groups. And peak total bilirubin (T.bil), peak direct bilirubin (D.bil), peak alanine aminotransferase (ALT), peak asparate aminotransferase (AST), and peak alkaline phosphatase (ALP) in infants with cholestasis were not significantly different. CONCLUSION: Aggressive parenteral amino acid supplementation in preterm infants were not associated significantly with the liver functions in this study.


Subject(s)
Humans , Infant , Infant, Newborn , Alanine Transaminase , Alkaline Phosphatase , Bilirubin , Birth Weight , Cholestasis , Incidence , Infant, Premature , Intensive Care, Neonatal , Liver , Medical Records , Parenteral Nutrition
4.
Journal of Clinical Neurology ; : 33-37, 2010.
Article in English | WPRIM | ID: wpr-57290

ABSTRACT

BACKGROUND AND PURPOSE: Multifocal seeding of the leptomeninges by malignant cells, which is usually referred to as leptomeningeal carcinomatous metastasis, produces substantial morbidity and mortality. The diagnosis of leptomeningeal metastasis is usually established by cerebrospinal fluid (CSF) investigation, including cytology, cell counts, protein, glucose, and a tumor marker such as carcinoembryonic antigen (CEA). This study examined the diagnostic value of CEA in the CSF. METHODS: We measured the CSF CEA level in 32 patients with leptomeningeal metastasis. The control group consisted of 19 cancer patients without leptomeningeal metastasis. CEA was measured by the chemiluminescent emission method. RESULTS: The CEA level was significantly higher in patients with leptomeningeal metastasis than in the control group (p<0.005). The level of CSF protein was higher and that of CSF glucose was lower in patients with leptomeningeal metastasis than in the control group (p<0.005). CONCLUSIONS: The CSF CEA level is useful for diagnosing leptomeningeal carcinomatous metastasis. The CSF levels of protein and glucose are also useful in the diagnosis.


Subject(s)
Humans , Carcinoembryonic Antigen , Cell Count , Glucose , Neoplasm Metastasis , Seeds
5.
The Journal of Korean Academy of Prosthodontics ; : 31-41, 2008.
Article in Korean | WPRIM | ID: wpr-72282

ABSTRACT

STATEMENT OF PROBLEM: It has been proved that Pleurotus eryngii Quel and Eleutherococcus senticosus have antiinflammatory action and not only stimulates the proliferation and activity of osteoblast but inhibits the generation and activity of osteoclast in vitro. Pleurotus eryngii Quel and Eleutherococcus senticosus are the main component of OPB-K(R). PURPOSE: The purpose of this study was to evaluate OPB-K(R) which enhances the healing rate of peri-implant bone and the bone mineral density. MATERIALS AND METHODS: Thirty six specially designed implants were installed in the tibia of rats. The group medicated with OPB-K(R) was the experimental group, and that without was the control group. hen the implant stability was measured by Periotest(R). Bone mineral density and histological measurement were conducted at the 2nd, 4th and 6th week Periotest(R) and bone mineral density values were analyzed statistically with independent t-test at 95% confidence level(P<0.05). RESULTS: The results of this study were as follows : 1. There was no statistically significant difference in Periotest(R) values between the experimental group and control group at the 2nd week, however, on the 4th and 6th week there was significant difference(P<0.05). 2. There was no statistically significant difference in bone mineral density between the experimental group and control group at the 2nd and 4th week, however on the 6th week there was significant difference(P<0.05). 3. Histological analysis showed difference in osseointegration on the 4th and 6th week between the groups. CONCLUSION: From the results, it is concluded that the OPB-K(R) medicated group showed statistically better results in bone density and stability than the control group. Clinically it would be better to medicate OPB-K(R) to patients for a long period of time after implantation to get superior results.


Subject(s)
Animals , Humans , Rats , Bone Density , Eleutherococcus , Osseointegration , Osteoblasts , Osteoclasts , Pleurotus , Tibia
6.
Korean Journal of Anatomy ; : 41-48, 2000.
Article in Korean | WPRIM | ID: wpr-650659

ABSTRACT

Degenerate oligonucleotide primed PCR is an useful technique to amplify whole genome and its the applications for fluorescent in situ hybridization and comparative genomic hybridization (CGH) were reported. For the CGH, topoisomerase and sequenase were recommended to use for the better hybridization. But adding the enzymes to PCR reaction per every cycle is labor-intensive and can easily contaminate PCR reaction. This study was carried out to prove the possibility of application of DOP-PCR to CGH without use of sequenase. Several combinations of CGH e.g., DOP-PCR amplified normal DNA vs. DOP-PCR amplified normal DNA, DOP-PCR amplified normal DNA vs. non-DOP normal DNA, DOP-PCR amplified normal DNA vs. DOP-PCR amplified MCF-600 cell line DNA, and non-DOP normal DNA vs. non-DOP MCF-600 DNA were performed. In addition, randomly selected microsatellite loci were tested to know whether DOP-PCR covers whole genome amplification. Apparently the DOP-PCR provides enough amount and size of DNA for CGH application and covers whole genome amplification. These results suggest that DOP-PCR can be used for CGH and genotyping.


Subject(s)
Cell Line , Comparative Genomic Hybridization , DNA , Genome , In Situ Hybridization, Fluorescence , Microsatellite Repeats , Polymerase Chain Reaction
7.
Korean Journal of Gastrointestinal Endoscopy ; : 113-118, 2000.
Article in Korean | WPRIM | ID: wpr-173470

ABSTRACT

BACKGROUND/AIMS: This study was undertaken to evaluate the usefulness of ERCP in patients with pyogenic liver abscess. METHODS: An endoscopic retrograde cholangiographic study of 70 consecutive cases of pyogenic liver abscess was conducted during the period from January, 1993 to December, 1997. Among 70 cases of pyogenic liver abscess, the male to female ratio was 1.69 :1, and the peak incidence was in the sixth decade. RESULTS: The common associated diseases were liver cirrhosis (11.4%), diabetes mellitus (8.5%), and malignancy (5.7%). The most common origins of the abscess in decreasing order of frequency were, transbiliary infection (51%), hematogenous spread, and trauma-associated causes. The ascending infection through the biliary tract as the etiology of liver abscess, has been common since the 1970's. The positive rate of abdominal US, CT, and ERCP in the diagnosis of the etiology of the liver abscess was 68, 82, 84% respectively. The treatments of the pyogenic liver abscess were, surgical drainage in 15 cases (21%) and percutaneous drainage in 51 cases (73%). Among 70 patients treated for pyogenic liver abscess, 12 patients had CBD stones and 11 patients were cured by EST. CONCLUSIONS: The most common origin of liver abscess is ascending infection through the biliary tract and ERCP may be a effective tool in the assessment and management of the etiology of pyogenic liver abscess.


Subject(s)
Female , Humans , Male , Abscess , Biliary Tract , Cholangiopancreatography, Endoscopic Retrograde , Diabetes Mellitus , Diagnosis , Drainage , Incidence , Liver Abscess , Liver Abscess, Pyogenic , Liver Cirrhosis
8.
Korean Journal of Nephrology ; : 787-791, 1999.
Article in Korean | WPRIM | ID: wpr-85211

ABSTRACT

The antiphospholipid antibody syndrome is cha- racterized by antibodies directed against either phos-pholipids or plasma proteins bound to anionic phos- pholipids. These antibodies have been characterized by lupus anticoagulants and anticardiolipin antibodies. Patients with the antiphospholipid antibody syndrome may display a constellation of clinical features including venous and arterial thrombosis, recurrent fetal losses, and thrombocytopenia. Although the majority of patients reported have a thrombotic microangiopathy, some have also seen membranous nephopathy as well as IgA nephropathy in a patient with anti-phospholipid antibody syndrome accompanying glo-merulonephritis. Authors experienced a 37-year-old male patient who presented with generalized edema at the moment of follow-up for primary antiphos-pholipid syndrome accampanying systemic thrombotic events. Anticardiolipin antibody-IgM positivity was detected by seroligic test but no evidence for systemic lupus erythematosus was found. Kidney biopsy showed mesangial IgA deposition without th throm-botic microangiopathy of gomerular capillaries and was diagnosed finally as primary antiphospholipid syndrome with IgA nephropathy. Patient's symptom was relieved with steroids and anti platelete agents and now he is being follow-up to out patient department. This case suggests some possibility that anticardiolipin antibody may induce the IgA nephropathy. Therefore clinician should have concern about the relationship between antiphospholipid antibody and immune mediate glomerulonephritis.


Subject(s)
Adult , Humans , Male , Antibodies , Antibodies, Anticardiolipin , Antibodies, Antiphospholipid , Anticoagulants , Antiphospholipid Syndrome , Biopsy , Blood Platelets , Blood Proteins , Capillaries , Edema , Follow-Up Studies , Glomerulonephritis , Glomerulonephritis, IGA , Immunoglobulin A , Kidney , Lupus Erythematosus, Systemic , Steroids , Thrombocytopenia , Thrombosis , Thrombotic Microangiopathies
9.
Korean Journal of Gastrointestinal Endoscopy ; : 486-490, 1999.
Article in Korean | WPRIM | ID: wpr-153518

ABSTRACT

A 57-year-old female with jaundice and right upper quadrant abdominal pain, was found on exploration to have squamous cell carcinoma of the common bile duct. Squamous cell carcinoma of the common bile duct is a very rare tumor, simulating adenocarcinoma in its clinical presentation and aggressiveness. Although no consistent causative factors for this tumor has been demonstrated, it has been theorized that the normal columnar epithelium of the bile duct under the influence of an inflammatory stimulus, can develop into squamous epithelium with the ongoing process leading to squamous metaplasia, and eventually carcinoma. Cholelithiasis has been implicated as a cause for bile duct cancer, which was manifested in this patient. The prognosis of this carcinoma was grave, despite all forms of surgical and medical management. A case of squamous cell carcinoma of the common bile duct is reported with a review of relevant literature.


Subject(s)
Female , Humans , Middle Aged , Abdominal Pain , Adenocarcinoma , Bile Duct Neoplasms , Bile Ducts , Carcinoma, Squamous Cell , Cholelithiasis , Common Bile Duct , Epithelium , Jaundice , Metaplasia , Prognosis
10.
Journal of Korean Society of Endocrinology ; : 612-616, 1998.
Article in Korean | WPRIM | ID: wpr-23013

ABSTRACT

Insulin autoimmune syndrome (IAS) includes fasting or reactive hypoglycemia, hyperinsulinemia and the presence of insulin-binding antibodies in patients who have never been exposed to exogenous insulin. This report concems a 29-year-old male patient with Graves disease who had history of having taken methimazole for two months, without any consequence, 6 months previously. However, when methimazole was administered again for three weeks, the patient suffered hypoglycemia during the next fourth week. He denied history of diabetes mellitus (DM), of taking any oral hypoglycemic agent or of having received insulin injection. Laboratory data showed total serum insulin level > 300 pu/mL, C-peptide reactivity (CPR) 8.0ng/mL and insulin antibody 89%. After stopping methimazole, he was treated with radioiodine (131I). There was no episode of hypoglycemic attack during 8 months of follow-up.


Subject(s)
Adult , Humans , Male , Antibodies , C-Peptide , Diabetes Mellitus , Fasting , Follow-Up Studies , Graves Disease , Hyperinsulinism , Hypoglycemia , Insulin , Methimazole
11.
Journal of the Korean Cancer Association ; : 1294-1298, 1998.
Article in Korean | WPRIM | ID: wpr-126322

ABSTRACT

Small cell lung cancer is the most aggressive tumor among lung cancers and has a greater tendency to be widely disseminated by the time of diagnosis. Without treatment, the median survial time of small cell lung cancer patients is only 2~4 months. However, though spontaneous regression of the malignant tumor has been frequently reported, spontaneous regression of the small cell lung cancer is rare. In this study a spontaneous regression of the small cell lung cancer is reported, along with a brief review of the literature. A 69 year-old woman was admitted for an evaluation for dyspnea. A chest roentgenogram obtained on admission revealed an abnormal mass shadow at the right hilus. She was diagnosed as having small cell lung cancer through a bronchoscopic biopsy. However this tumor regressed spontaneously without specific treatment after 12 months.


Subject(s)
Aged , Female , Humans , Biopsy , Diagnosis , Dyspnea , Lung Neoplasms , Small Cell Lung Carcinoma , Thorax
12.
Journal of the Korean Surgical Society ; : 759-764, 1991.
Article in Korean | WPRIM | ID: wpr-181837

ABSTRACT

No abstract available.

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