ABSTRACT
Glucagoma is rare disease and has been reported only 100 cases so far worldwidely. The experience of this disease in our country is also lacking. The associated symptoms and signs can be characterized by necrolytic migratory erythematous lesion of the skin, hypoaminoacidemia, diabetes, weight loss, anemia, diarrhea, thrombocytopenia, glossitis. Among these, necrolytic migratory erythematous lesion of the skin is particulary considered as specific in this disease entity. In some cases, glucagonoma is diagnosed after metastasis to liver or bone marrow. Our patient initially diagnosed as having multiple metastatic adenocarcinoma of the liver. But subsequent development of the dermatologic manifestation enabled us to consider this rare disease. The constitutional symptoms and skin lesion abates rapidly at receiving Octreotide, somatostatin analogue, whereas no remarkable change observed after administration of the Zinc and aminoacid.