ABSTRACT
BACKGROUND: Systemic inflammatory reaction syndrome (SIRS) describes the systemic inflammatory process and can be seen following a wide variety of insults. This is the leading cause of morbidity and mortality for patients admitted to the ICU. The arterial keton body ratio (AKBR), serum lactate level and the thyroid hormones, thyroid stimulation hormone (TSH), thyroxine (T4), free thyroxine (FT4) and triiodothyronine (T3) deteriorate in critically ill patients with a poor prognosis. The APACHE (Acute Physiology, and Chronic Health Evaluation) III and multiple organ failure (MOF) score have been known as good prognostic predictors in the ICU. The object of this study was to compare the AKBR, lactate and thyroid hormone levels, and the APACHE III and MOF score between the survivors (SV) and nonsurvivors (NSV) and the correlation among the above predictors. METHODS: 35 patients with no known thyroid or liver disease who were admitted to the SICU with the criteria of SIRS were selected. Arterial blood was drawn for the AKBR, and the lactate and thyroid hormones studies. The APACHE III and MOF scorings were done in the first 24 hours of SICU admission. RESULTS: There were no significant difference between SV and NSV except APACHE III (SV: 68.7 24.6, NSV; 92.9 27.6). There were significant correlations between the APACHE III and MOF score (R = 0.688, P<0.01), APACHE III and lactate (R = 0.575, P<0.01), and MOF score and lactate (R =0.483, P<0.01). Thyroid hormones had positive correlations among themselves only. CONCLUSIONS: We conclude that APACHE III is the only good predictor of mortality. The APACHE III, MOF score, and lactate level show good correlations indicating the severity in condition of the ICU patients.
Subject(s)
Humans , APACHE , Critical Illness , Lactic Acid , Liver Diseases , Metabolism , Mortality , Multiple Organ Failure , Physiology , Prognosis , Survivors , Thyroid Gland , Thyroid Hormones , Thyroxine , TriiodothyronineABSTRACT
Giant aneurysms present challenging problems with conventional techniques because the lesion is in a difficult area or lacks a definitive aneurysmal neck. For the safety of operation and protection from cerebral ischemia, deep hypothermic circulatory arrest and cerebral protection with barbiturate is considered a useful technique. But deep hypothermia may produce myocardial depression and coagulopathy with high mortality. We report our experience with cardiopulmonary bypass with deep hypothermic circulatory arrest for the management of a patient with giant aneurysm of basilar artery and mild coronary artery stenosis. No significant complications were related to the technique of cardiopulmonary bypass with deep hypothermic circulatory arrest.
Subject(s)
Humans , Aneurysm , Basilar Artery , Brain Ischemia , Cardiopulmonary Bypass , Circulatory Arrest, Deep Hypothermia Induced , Coronary Artery Disease , Coronary Stenosis , Coronary Vessels , Depression , Hypothermia , Mortality , NeckABSTRACT
Giant aneurysms present challenging problems with conventional techniques because the lesion is in a difficult area or lacks a definitive aneurysmal neck. For the safety of operation and protection from cerebral ischemia, deep hypothermic circulatory arrest and cerebral protection with barbiturate is considered a useful technique. But deep hypothermia may produce myocardial depression and coagulopathy with high mortality. We report our experience with cardiopulmonary bypass with deep hypothermic circulatory arrest for the management of a patient with giant aneurysm of basilar artery and mild coronary artery stenosis. No significant complications were related to the technique of cardiopulmonary bypass with deep hypothermic circulatory arrest.