The Inhibitory Effects of 5-fluorouracil on Experimental Proliferative Vitreoretinopathy

Proliferative vitreoretinopathy (PVR) is the main cause of failure in retinal reattachment surgery, Vitrectomy combined with pharmacologic therapy to inhibit proliferating and contracting epiretinal membranes appears to be a promismg approach in the management of PVR. We investigated the inhibitory effect of intravitreal 5-fluorouracil (5-FU) on experimental PVE induced by intravitreal injection of homologous dermal fibroblast in pigmented rabbits. At 6 weeks after intravitreal injection, Goup I (fibroblast only), Group II (early treatment with 1mg of 5-FU), and Group Ill (delayed treatment with 1mg of 5-FU) developed the retinal detachment in 85.7%, 33.3%, and 58.3% respectively. The rate of retinal detachment was lower in treatment groups than in non-treatment group, but there was a statistically significant difference only between non-treatment group (Group I) and early-treatment group (Group II) (p<0.05). In the group that only 5-FU was injected (Group IV), the retinas were preserved in normal clinically and pathologically. These results show that 5-FU may exert a significant anti proliferative effect on intraocular proliferative disorders including PVR especially if the drug is administered more earlier.

The Clinical Report on Seven Cases of Epikeratoplasty

After the first description of epikeratoplasty for the correction of aphakia, it has been widely used in high myopia and keratoconus for improvement of visual acuity. Seven epikeratoplasties were performed on five high myopia and two keratoconus patients showing intolerance to eye-glasses and contact lens, with the mean follow-up period of 9.7 months. In high myopia, mean spherical equivalent decreased from -15.90D to -2.05D postoperatively. In keratoconus, mean keratometric value decreased more than 4.94D postoperatively and the progression of disease stopped. All patients showed an imporvement in thei uncorrected visual acuity and best corrected visual acuity. In all cases, reepithelialization completed in 4-23 days (mean 14 days).

Morphometric Analysis of the Corneal Endothelial Cells in Normal Korean

To investigate the morphometric characteristics of the corneal endothelial cells in normal Korean, specular microscope has been used in 84 eyes of 42 normal Korean volunteers, 42 eyes in male, 42 eyes in female ranging in age from 5 to 71 years of age. We have analyzed cell density, cell area, coefficient of variation of cell area (CV), perimeter, shape factor, hexagonality, and side lengths, and compared the changes in each parameters according to age, right and left eye, and sex. The mean cell density was 3025 cells/mm2, and mean hexagonality was 67.01%. The values in these two parameters decreased with age (p

A Case of Ureteral Polyp / 대한비뇨기과학회지

Primary tumors of the ureter are usually malignant and rare, a few are benign. Benign tumors arising from mesoderm are especially rare. But, recently the incidence rate was progressively increased due to developed methods of diagnostic procedures. We herein report a case of ureteral polyp in the left ureteropelvic junction with a brief review of literatures.

Torsion of Spermatic Cord / 대한비뇨기과학회지

Authors experienced a case of torsion of spermatic cord recently and reviewed the literatures. The patient was a 33 year-old male with chief complaints of sudden onset on left scrotal swelling and testicular pain. Physical examination was not significant except positive Prehn`s sign on the involving side of testicle. Under the diagnosis of torsion of spermatic cord, he was performed of left orchiectomy and the opposite side orchiopexy.