Intensity-modulated radiation therapy in head-and-neck cancer, first report in Thailand.

OBJECTIVE: This is the first report in Thailand to evaluate the efficacy of using intensity-modulated radiotherapy (IMRT) in the primary treatment of head-and-neck cancer. MATERIAL AND METHOD: From July 2005 to March 2006, eighteen patients with head and neck cancer were treated with IMRT, fourteen of which were nasopharyngeal cancer. The median age at diagnosis was 52 years (range 23-58 years). The treatment plan composed of two sequential plans for PTV-low risk (50Gy in 25 fractions) and PTV-high risk (20Gy in 10 fractions). Chemotherapy was given to 13 patients with locoregionally advanced disease (stage T3/T4 and N2/3) using cisplatin (n = 3) or carboplatin (n = 10) every 3 weeks during the course of radiation therapy. RESULTS: The median overall treatment time was 49 days (range, 43-57 days), and 77.8 percent of the patients completed 35 fractions within 50 days. The clinical complete response and partial response rates at 3 months after complete radiation were 71.4% and 28.6%, respectively. However at the median follow-up of 5.6 months, the complete response rate increased to 89%. Treatment break during RT range from 3 to 7 days, was observed in three patients. All of them received concurrent chemoradiation. No distant metastasis was noted. CONCLUSION: The authors' experience of using concurrent chemotherapy with IMRT for a cohort of patients with head and neck carcinoma showed a very high rate response rate at early follow-up. Long-term clinical outcome is expected.

The pectoralis major myocutaneous flap: applications and complications in head and neck reconstruction.

Ninety-six pectoralis major myocutaneous flaps were used in the head and neck reconstruction of 93 patients who underwent extirpation of cancer. The utilization of the pectoralis major myocutaneous flap included 50 tongue replacements, 19 hypopharynx and pharyngoesophageal closure, 11 oral mucosal closure and external skin replacement, 7 soft tissue coverage of the reconstruction plate, 3 soft tissue protection of the great vessels at the neck and 6 correction of the wound breakdown from failure of the other flap reconstruction. The major complication, which included total flap loss, partial skin paddle loss, orocutaneous fistula, dehiscence and plate exposure, was 17.7%. The overall complication rate was 54.2% and most of them were healed by conservative management. The pectoralis major myocutaneous flap is feasible and reliable for immediate reconstruction of various defects in the head and neck area. The pectoralis major myocutaneous flap should be the suitable flap for the advanced-staged cancer patient with a limited life expectancy.