ABSTRACT
Transient acantholytic dermatosis was described by Grover. Its definite cause and pathogenesis is unknown. A 22-year-old man presented to our out-patient department with multiple itchy vesicles and pustules on the neck and chest. The biopsy was done and histopathology findings revealed focal acantholytic dyskeratosis. Case was diagnosed as Grover's disease. Patient was given vitamin A 50000 IU per day and later dapsone was added. Patient was advised to avoid sunlight and heat. This is the first case of biopsy confirmed Grover's disease from Nepal
ABSTRACT
Erythromycin is a macrolide antibiotic active against many gram-positive infections and few gram-negative bacteria, as well as mycoplasmas, spirochetes, chlamydiae and rickettsiae. Dermatological reactions appear to be rare with erythromycin and mainly include maculopapular rashes, pruritus, urticaria, and angioedema, Reports of morbiliform rashes due to erythromycin are rare. We report a case of morbiliform reaction due to erythromycin in a patient suffering from herpes zoster with established causality, severity and preventability assessments. Upon development of the adverse drug reaction, we stopped the drug and managed the patient with systemic corticosteroids