ABSTRACT
Background: Diabetic patients have a bigger probability of getting dyslipidemia, high blood pressure, and fleshiness. This manner of dyslipidemia remains for the most part unknown or diagnosed late and beneath treated in high risk populations, like patient with type- two polygenic disorder. The aim of the study is to research the connection between body fluid lipid profile in type-2 diabetic patients. Methods: A cross sectional study done on one hundred patients with kind two polygenic disorders. The participants were already diagnosed as kind two diabetics and undergoing treatment. in line with NCEP-ATPIII guideline, hypercholesteremia is outlined as TC>5.2 mmol/l, high LDL- C once price >2.6 mmol/l, hypertriglyceridemia as TG >3.8 mmol/l and low HDL-C once price <1.0 mmol/l. Dyslipidemia was outlined by presence of 1 or quite one abnormal body fluidlipidconcentration.Diabetes disorderwasoutlinedas American diabetesAssociation (ADA) criteria. Results: ‘The mean age of the males (58.1±2.3) weren't statistically completely different (p=0.6402) from that of the females (57.1±1). The mean waist circumference (WC), hip circumference (HC), Body adiposity Index (BAI) and Body Mass Index (BMI) of the feminine subjects were considerably high as compared with the male subjects (p=0.0008, 0.0002, 0.000 and 0.0002 respectively). Among the diabetic people, 59 (59%) people had just one abnormal lipid profile parameter, 34 (34.0%) had 2 abnormal lipid parameter and 27 (27%) people had quite two abnormal lipid profile parameters. Conclusion: We tend to terminate that early identification is accomplished through comparatively cheap blood testing and will be utilized for screening bad diabetic patients for timely intervention with lipid lowering medicine.
ABSTRACT
Background: The management of PROM has often been adilemma in obstetrics. Different regimens are followed indifferent centres all over the world for management of PROM.This study is aimed to compare the safety and efficacy ofsublingually equivalent dose regimen administered vaginally forinduction of labour in patient with PROM with poor Bishop’sScore.Material & Methods: A prospective randomised controlled trialdone on 60 Patients of PROM admitted in labour room ofGovernment Medical College, Dungarpur, as per inclusion andexclusion criteria. Group 1- Received 25µg misoprostol,intravaginally 4 hourly up to maximum of 3 doses, placed inposterior fornix. Group 2- Received 25 µg misoprostol,sublingually 4 hourly up to maximum of 3 doses. Foetal heartand labour progress monitoring was done. Before every dose apervaginum examination was performed to assess the Bishopscore.Results: Our study showed that the foetal distress (foetal heartrate (FHR) abnormalities; FB<120bpm, FT >160bpm) wasmost common intrapartum complication in both groups(13.33% each). Mean induction delivery interval in sublingualgroup was 8.13±4.29 hours and in intravaginal group was7.31±4.11hours. Majority of women in both groups deliveredvaginally; 25 patients (83.33%) in intravaginal and 26 patients(86.66%) in sublingual group. 2 patients in intravaginal and 1patient in sublingual group had atonic PPH. However nopatient required blood transfusion. None had retained placenta.There was no maternal mortality.Conclusion: We concluded that both sublingual andintravaginal route of administration of 25µg misoprostol areequally effective in achieving favourable Bishop’s score,vaginal delivery rates, with comparable induction to deliveryintervals without increasing the caesarean rates and thepostpartum complications.
ABSTRACT
Chronic myeloid leukemia [CML] is a myeloproliferative disorder with a unique genetic rearrrangement, the Philadelphia chromosome. High reactive oxygen species [ROS] levels favor oxidative stress, which could play a vital role in normal processes and various pathophysiologies including neoplasm. Biomarkers of oxidative stress are measured as products of oxidized proteins and lipids. Plasma levels of protein carbonyl [PC], thiobarbituric acid reactive substances [TBARS] and total lipid hydroperoxide [LOOH] were used as biommarkers of oxidative stress in the past. The aim of this study was to evaluate the products of protein oxidation and lipid peroxidation in plasma as biomarkers of oxidative stress in CML patients. The study included 40 CML patients and 20 age- and sex-matched healthy voluntteers. Of 40 CML patients, 28 were in chronic phase [CML-CP] and 12 in accelerated phase [CML-AP]. Plasma levels of PC, TBARS and LOOH as biomarkers of oxidative stress were evaluated by spectrophotometric methods. There were significant differences [P<.05] in plasma levels of PC, TBARS and LOOH in CML, CML-CP and CML-AP patients as compared to controls. PC, TBARS and LOOH might reflect oxidative stress in CML patients and might be used as biomarkers in such patients