ABSTRACT
Oren-to was orally administered to 18 patients with acute aphthous stomatitis, followed by an examination of the results. As a control, the natural course of the condition was observed without treatment in five patients, and local application of oral steroid ointment (dexarutin ointment for the oral cavity; 0.1%) was given to an additional five patients.<br>Compared with the control groups, the number of days until the disappearance of pain as well as the attainment of a complete cure was reduce significantly in the Oren-to group. When Oren-to was abministerad to two patients with chronic recurrent stomatitis, transient remission of the symptoms was noted, as in the acute Stomatitis cases, but the condition recurred. In one case, Oren-to was continued for one month but proved ineffective; replacement with Rikkushi-to brought about a disappearance of the condition after one week of treatment. In another patient, the condition was cured after administration of Oren-to for four months, and has not recurred to date.<br>These findings suggest that Oren-to is useful in the treatment of aphthous stomatitis, especially in the acute phase.