ABSTRACT
Resistin is a newly discovered peptide hormone with impact on insulin sensitivity was proposed as a new mechanism to explain the pathogenic sequence of adipocyte-obesity-insulin resistance. This research aimed to determine serum resistin concentration levels in adolescents and the relationship between resistin concentration and body mass index (BMI), in selected high school students in Mahasarakam province. The research protocol and 77 consented students who enrolled in this study were ethical approved by Mahasarakam research ethic committee division. The students weight, height, BMI, fasting blood sugar (FBS) and triglyceride (TG) were examined during March to June 2008. This study found that: 16 male and 61 female adolescent students with average weight 71.27±13.87 kg, height 1.6±0.07 m, BMI 27.67±4.24 kg/m² , biceps skinfold thickness 15.27±6.89 mm, triceps skinfold thickness 23.55±7.54 mm, TG 77.13±43.92 mg/dL, FBS 87.74±8.21 mg/dL and resistin 5.69±0.93 mg/dL. The weight and height of male is higher than female (p =0.003, p \< 0.001 respectively), but biceps skinfold thickness, triceps skinfold thickness, TG of female is higher than male. Resistin was detected in female; concentrations ranged from 3.83 mg/dL to 7.82 mg/dL and in male 3.91 mg/dL to 6.52 mg/dL. In female resistin levels were higher (5.87±0.84) than male (4.98±0.94) (p \< 0.001). The relationship analysis found that: resistin serum levels in both male and female related to BMI, biceps skinfold thickness, triceps skinfold thickness statistical significantly. The furthermore it should be the parameter used as association of serum resistin with markers of obesity (eg. weight, BMI, FBS) was strongly statistical significantly (p \< 0.05) in both gender groups, this may be determinant to indicated insulin resistance prior fasting blood sugar was elevated, but vise-versa for FBS in male.