ABSTRACT
Objective To detect the levels of anti-measles antibody in a healthy population in Jin-shan District of Shanghai and to provide references for making a better immunization strategy against measles in this area. Methods Stratified sampling was used to collect 390 serum sample in 12 age groups with an equal number of males and females as well as resident and floating population. Indirect enzyme-linked immu-nosorbent assay (ELISA) was performed to detect the concentrations of IgG antibody against measles in dif-ferent groups. Results The overall positive rate and protective rate of anti-measles antibody were 78.21% and 41.28%, respectively. No significant difference in the positive rates of antibody was found between males and females, or resident and floating population (P>0.05). Antibody levels varied significantly among different age groups(χ2=191.214,P<0.01). More than 80.00% of the people aged≥1 year were positive for anti-measles antibody and the positive rates in children 3 to 6 years old and people aged ≥40 years reached 100% and over 90.00%,respectively. Infants under 8 months of age,having the lowest posi-tive rate of antibody(10.00%),were susceptible to measles. The highest protective rate was found in chil-dren aged 8 months to 9 years,followed by that in people≥40 years. Levels of anti-measles antibody in peo-ple aged 10 to 39 years mainly ranged from 200 mIU/ml to 800 mIU/ml. No significant difference in anti-body levels was found among people aged≥8 months who had different immunization histories(χ2=1.140,P>0.05). Conclusion The average level of anti-measles antibody was high in Jinshan District in 2015,in-dicating that the people in that area had a relatively high immunity to measles,but the positive rate of anti-body needed to be further improved. Infants under 8 months old and people 10 to 39 years old were the main susceptible groups. It is suggested that measles vaccination efforts should be focused on susceptible popula-tion and women of childbearing age to improve herd immunity.
ABSTRACT
Objective To explore the effect of craniotomy operation and keyhole minimally invasive opera-tion in the treatment of patients with cerebral hemorrhage .Methods 90 patients with cerebral hemorrhage were ran-domly divided into control group and observation group .45 cases in the control group were given conventional cranioto-my to clear hematoma ,45 cases in the observation group received keyhole minimally invasive operation .The operation time,blood transfusion amount , hematoma clearance rate , residual hematoma volume , GOS scale were recorded and compared between the two groups.Postoperative follow-up for one year,the rehospitalization rate,mortality,the Barthel index score,curative effect were compared .Results The operation time and blood transfusion amount of the observa-tion group were (92.5 ±18.1) min,(125.0 ±23.4) mL,which were significantly less than (125.6 ±20.3) min, (325.0 ±104.5)mL of the control group (P0.05).The effective rate of the ob-servation group(91.1%) was obviously higher than that of the control group (62.2%),the difference was statistically significant(P<0.01).The patients were followed up for one year postoperation ,the rehospitalization rate and mortali-ty of the observation group were 20.0% and 5.0%,which were significantly lower than those of the control group (42.1%,15.8%)(P<0.05).While the Barthel index score of the observation group was higher than that of the control group,the difference was significant (P<0.05).Conclusion Keyhole minimally invasive operation in the treatment of cerebral hemorrhage has good clinical curative effect ,with advantages of simple operation ,less trauma, good surgery prognosis ,which is worthy of further clinical promotion .