ABSTRACT
ObjectiveTo determine the death level， change trend and life loss of pancreatic cancer among residents in Yuyao， and to provide scientific reference for the prevention and control of pancreatic cancer. MethodsThe death monitoring data of registered residents in Yuyao from 2014 to 2021 were collected to calculate crude mortality rate（CMR）， standardized mortality rate （SMR）， potential years of life lost （PYLL）， average years of life lost （AYLL）， PYLL rate （PYLLR）， average annual percent change （AAPC） and other indicators. ResultsFrom 2014 to 2021， 860 cases of pancreatic cancer died in Yuyao， accounting for 6.25% of all malignant tumor deaths in the same period. The average annual mortality rate was 12.86/100 000， the age-standardized rate by Chinese standard population （ASRC） was 7.08/100 000， and the age-standardized rate by world Segi’s population （ASRW） was 5.17/100 1000. The CMR showed an upward trend in eight years （t=-5.076， P=0.002）. 493 men died of pancreatic cancer with an average annual mortality of 14.95/100 000， ASRC of 8.13/100 000， and ASRW was of 6.24/100 000. 367 women died of pancreatic cancer with an average annual mortality rate of 10.82/100 000， ASRC of 6.02/100 000， and ASRW of 4.14/100 000. The mortality rate of men was higher than that of women （χ2=22.191， P<0.001）. The minimum death age of pancreatic cancer is 27.52 years old， the maximum death age is 94.52 years old， and median age （Q1， Q2） of death was ［71.13（63.21， 78.87）］ years old. The death age of men ［69.61（62.30， 77.06）］ was less than that of women ［72.48（64.63， 81.09）］ （t=-3.820， P<0.001）. The mortality rate of pancreatic cancer showed an upward trend with age （χ2trend=1 110.844， P<0.001）， and the 75 year old mortality rate （75.58/100 000） fell after reaching the peak. PYLL caused by death of pancreatic cancer in 8 years was 9 775.00 person years， AYLL was 14.33 person years， and PYLLR was1.53‰. ConclusionPancreatic cancer is an important cause of death for residents in Yuyao， which has a huge loss of life. It is necessary to formulate targeted prevention and control strategies， with the middle-aged and elderly as the key population， to reduce the incidence and death of pancreatic cancer.
ABSTRACT
A fluorescence nanosensor based on an easily prepared fluorescent molecule, 1-oxo-1H-phenalene-2,3-dicarbonitrile (OPD), was developed for highly sensitive detection of glucose.Under the catalysis of horseradish peroxidase (HRP), 3,3′,5,5′-tetramethylbenzidine (TMB) was oxidized into oxidized TMB (oxTMB) by H2O2.And the fluorescence of OPD was quenched by the intense absorption of the formed oxTMB, thus realizing effective quantitative detection of H2O2.The linear range was 0.05-0.8 μmol/L and 1-10 μmol/L respectively, with limit of detection of 0.02 μmol/L.Besides, on the basis of transformation of glucose into H2O2 through the catalysis of glucose oxidase, this nanosensor could be further exploited for highly sensitive detection of glucose.The TMB-HRP-OPD sensor exhibited linear range of 0.1-3.0 μmol/L and 4.0-30 μmol/L respectively for detection of glucose, with limit of detection of 0.02 μmol/L.Furthermore, it was successfully applied to the determination of glucose in real human serum and the results were in good agreement with the clinical data.
ABSTRACT
Objective:To analyze the anti-infection therapy for one lung cancer patient with agranulocytosis and fever after chemo-therapy to provide pharmaceutical care and support for the rational anti-infection drug use in the patient. Methods: Clinical pharma-cists analyzed the drugs used in the patient and provided pharmaceutical care for doctors according to the examination results and diag-nosis of the patient. Results:By participating in the treatment plan, clinical pharmacists ensured the treatment for the patient was safe and effective. Conclusion:Clinical pharmacists should assist doctors in making out the treatment plan according to patients’ situation in order to promote rational drug use in clinics and reflect the value of pharmaceutical care.