ABSTRACT
Background: Peyronie’s disease is an inflammatory, fibroticpenile disorder affecting men in age range of 19-83 years. Itoccurs as an acute or chronic phase and rarely cases resolveon their own. Several treatment options are available includingoral, intralesional and surgery. Although several clinical trialshave been performed, they lack significant and corroboratedresults hence there is a need to attempt prospective researchto elucidate the most effective therapies. The aim of this studyis to determine the efficacy of intralesional injection ofverapamil over normal saline.Methods: This was a randomized parallel group studyconducted between March 2013 and February 2017 whichrandomized patients with Peyronie’s disease into two groups toreceive verapamil or normal saline intralesional injections, withinclusion criteria of penile curvature with or without plaque.After 6 biweekly injections, all above parameters andsatisfaction score was reexamined. Patients were evaluated byhistory, physical examination, questionnaire, ultrasonographyand color Doppler study of the penis.Results: A total of 53 patients were enrolled (verapamil, n=28;control, n=25). Overall, among verapamil group attenuatedcurvature, erectile dysfunction and reduced plaque size werefound in 82%, 64.2%, 67.8% of and 60.7of patientsrespectively. Pain decreased in both groups considerable to97% and 91%. Overall satisfaction level was higher inverapamil group that is82% to control group of 40%.Conclusion: Intralesional verapamil is a good treatmentchoice with absence of invasive procedures and overall goodsuccess rate and patient acceptability.