Assessment of risk of developing diabetes using Indian diabetes risk score in the urban field practice area of Rajarajeswari Medical College and Hospital, Bangalore

Background: Diabetes is one of the largest global health emergencies of the 21st century. As per International Federation of Diabetes some 425 million people worldwide are estimated to have diabetes. The prevalence is higher in urban versus rural (10.2% vs 6.9%). India had 72.9 million people living with diabetes of which, 57.9% remained undiagnosed as per the 2017 data. The objectives of the present study were to identify subjects who at risk of developing Diabetes by using Indian diabetes risk score (IDRS) in the Urban field practice area of Rajarajeswari Medical College and Hospital (RRMCH).Methods: A cross sectional study was conducted using a Standard questionnaire of IDRS on 150 individuals aged ≥20 years residing in the Urban field practice area of RRMCH. The subjects with score <30, 30-50, >or =60 were categorized as having low risk, moderate risk and high risk for developing diabetes type-2 respectively.Results: Out of total 150 participants, 36 (24%) were in high-risk category (IDRS≥60), the majority of participants 61 (41%) were in the moderate-risk category (IDRS 30–50) and 53 (35%) participants were found to be at low-risk (<30) for diabetes. Statistical significant asssociation was found between IDRS and gender, literacy status, body mass index (p<0.0000l).Conclusions: It is essential to implement IDRS which is a simple tool for identifying subjects who are at risk for developing diabetes so that proper intervention can be carried out at the earliest to reduce the burden of diabetes.

Angioedema caused by over the counter use of dicyclomine hydrochloride and paracetamol fixed dose combination in a child: a case report

Authors describe a case of angioedema in a male child due to over-the-counter (OTC) use of fixed dose combination (FDC) of Tab. dicyclomine hydrochloride (20mg) and paracetamol (500mg) for abdominal pain. Use of OTC drugs in children without a doctor抯 suggestion can lead to unnecessary medication use and is not free of risks. Here, there is a probable causal relationship between the suspected drug and angioedema according to WHO-UMC criteria for Causality Assessment. This case was also reported to the Pharmacovigilance Programme of India (PvPI) through PvPI ADR android application.

Aberrant Maxillary First Molar Mimicking Mandibular First Molar – An Unusual Case Report.

The tooth development involves a complex series of genetic interactions involving growth factors, transcription factors, signal receptors and diffusible morphogens that interact within independent signalling pathways. This report describes a case of occlusal dysmorphology and a root variance of maxillary right first molar which almost mimicked that of a rotated mandibular 1st molar. The cuspal variation of mesiodistal was same as that of 36. This kind of variation may be due to Genetic or Environmental factors or interplay of both. So there is a need for research to be done in this aspect in larger group.

Phytochemical Investigation and Cytotoxic Activity of Methanolic Extract of Alpinia Galanga.

Phytochemical investigation of methanol extract of seeds of the Alpinia galanga led to the isolation of one new diterpenoid, along with three known compounds. Their structures were established on the basis of NMR and mass spectroscopic analysis. In addition, all the isolates were tested for their cytotoxicity against lung cancer (H522), leukemia K562, breast cancer (MCF-7/ADR) and prostate cancer (DU145) cancerous cell lines. The new Compound 1 has shown good cytotoxic activity.

Endo-Orthodontics- Inside And Outside The Root - Interactions: Tasks To Be Tackled.

Endodontic treatment of teeth is now a common procedure across all age groups, either as a result of caries or trauma. Furthermore, as the number of adults undergoing orthodontic treatment increases, the number of orthodontic patients presenting with restored teeth or having endodontic treatment is on the rise. Diagnosis and treatment planning for these patients require an evidence based approach to achieve a good functional and esthetic results. Orthodontic treatments have profound effect on pulp and periodontal ligament which can lead to root resorption or loss of vitality which remain as orthodontic scars. Literature regarding occurrence of root resorption in vital teeth and teeth having endodontic treatment, the influence of trauma, the provision and outcome of endodontic treatment when attempted during the course of orthodontic therapy and the adjunctive role of orthodontics in facilitating good endodontic output are inconclusive till now. The integrated endodontic and orthodontic treatment in such situations will give optimum results. This article mainly focuses on orthodonticendodontic interactive tasks to be tackled that are often encountered in clinical practice which play an important role in treatment planning and its outcome.