ABSTRACT
Introduction: Thyroid disorders in pregnancy are amongthe common endocrine disorders. During pregnancy severalphysiological changes occur in maternal thyroid function andfailure to adapt to these changes result in thyroid dysfunction.Thyroid dysfunctions have many adverse effects on motherand fetus, like miscarriages, preeclampsia, eclampsia,placental abruption, preterm delivery, low birth weight, postpartum haemorrhage, neonatal hypothyroidism and impairedneurological and intellectual development of fetus. Studyaimed to find out the prevalence of thyroid dysfunction inpregnancy and to know maternal and foetal outcome.Material and methods: This cross sectional clinical studywas carried out at Obstetrics and Gynecology departmentin collaboration with Biochemistry Department, IGIMS,Patna, Bihar from August 2018 to August 2019 including100 pregnant women with single intrauterine pregnancy infirst trimester between 6-14th weeks of gestation. TSH levelwas estimated in all the pregnant women along with FT3,FT4, and Anti TPO Ab. According to the thyroid profile,patients were divided into 4 groups- Normal/ Subclinical/Overt hypothyroidism and hyperthyroidism and followed tilldelivery for maternal and perinatal outcome.Results: In our study of 100 patients, 87 were found to havenormal thyroid function and 13 cases were having subclinicalhypothyroidism, using a cut off TSH level of 2.5-10uIU/ml inAntiTPO Ab positive and 4-10uIU/ml in AntiTPO Ab negativecases. No case of hyperthyroidism or overt hypothyroidismwas found. These 100 patients were divided into two groups.Patients having normal thyroid function were included inGroup 1 and patients with subclinical hypothyroidism wereincluded in group 2. In subclinical hypothyroidism group5(38.46%) cases were AntiTPO Ab positive and 8 cases wereAntiTPO Ab negative.Conclusion: Our study concludes that there is high prevalenceof subclinical hypothyroidism (13%) in pregnant womenduring 1st trimester. No significant difference was seen inmaternal and foetal outcome between euthyroid patients andtreated subclinical hypothyroid patients.