ABSTRACT
Background: The objective of the study is to estimate platelet volume indices in patients of cerebral ischemic vascular disease. Methods: The present study was conducted on 170 subjects in Department of Medicine, NIMS Medical College and Hospital, Jaipur, Rajasthan over eighteen months. The study was conducted on 60 patients admitted in the wards and ICU under the Department of Medicine and 110 controls who were the normal and healthy during the study period. In this study the values of platelet indices – MPV, PDW and platelet count were observed in patients of cerebral ischemia. It was found that large platelets contribute to the prethrombotic state in ischemic syndromes and they may play a specific role in infarction. Because larger platelets are haemostatically more active and hence, their presence is probably a risk factor for developing thrombosis. Statistical analysis was done using Chi – square test, unpaired ‘t’ test and ANOVA test. A p value <0.05 was considered statistically significant. Results: In this study it was found that in cerebrovascular disease patients, MPV was 10.30±0.83 fL, PDW was 14.50±0.55 fL, platelet count was 260×109 ± 29×109 /L while in control, MPV was 8.14± 0.72 fL, PDW was 10.71±0.48 fL, platelet count was 285×109 ± 50 ×109 /L. MPV and PDW were higher and platelet count lower in cerebrovascular disease group and a highly significant difference (p<0.001) was found on comparing with controls. Conclusion: In this study, it was found that MPV and PDW were raised in cerebrovascular disease suggestive of statistically highly significant when compared to normal control group.
ABSTRACT
Background: To study the effect of multidrug treatment regimen in the patient of DCMP (Dilated cardiomyopathy) compared to single drug/ low dose multi drug regimen. Methods: A total of 40 patients diagnosed with DCMP (both ischemic and non-ischemic) in the last 5 years attending to Cardiology OPD/ Inpatients in National Institute of Medical sciences, Jaipur were enrolled in the study. Out of 40 patients, 20 were kept on routine treatment regimens like diuretics, beta-blockers, angiotensinogen converting enzyme inhibitor/ Angiotensin receptor blockers (ACEI/ARB), either of them or all three of them in low dose. The other 20 patients were started on mineralocorticoid receptor antagonists (MRA’s), beta-blockers, ACEI all together with gradual increments of doses to a higher level. Both these groups were followed for 2 years and we found that patient groups with effective high dose multi drug regimen has good event free survival rate compared to traditional single drug /low dose multiple regimen. Tests of statistical significance were done using Chi-square Test. Results: Out of 20 patients in normal (routine treatment regimen) 12 patients presented with congestive cardiac failure (CCF) ,15 with dyselectrolemia ,10 with hypotensive episodes and 6 deaths were seen compared to 5 patients with CCF, 5 with dyselectrolemia, 8 with hypotension and 2 deaths were seen in high dose multi drug regimen. Out of this episodes of CCF (p=0.002), dyselectrolemia (p=0.001) are statistically significant. Conclusion: High dose MDR is preferable for event free survival rate in patients of DCMP.
ABSTRACT
We report a case of Broken heart Syndrome in a 56 year old Postmenopausal women suffered while undergoing simple biopsy procedures for vocal cord polyp that lead to physical, mental and financial burden both for the patient and doctors. The diagnosis of this case is made by a team of cardiologists based on clinical and echocardiographic findings.
ABSTRACT
We report a case of DORV in an 18-year-old female patient presented to NIMS Medical College and Hospital with unrelated symptoms of urinary tract infection. Diagnosis of this case is made by 2D-echocardiography with cardiologist consultation.
ABSTRACT
We report a case of Toxic Epidermal Necrolysis (TEN) in a 10 year old male child resulted from inadvertent anti-epileptic usage. Steven-Johnson Syndrome (SJS) /TEN has been seen as a side-effect of many drugs like Cotrimoxazole, Phenytoin, Carbamazepine, Valproic acid, NSAID’S, Allopurinol. Etc., but TEN in a patient who is on valproic acid with addition of lamotrigine is rare which is a point of interest in our case which was successfully treated with Intravenous immunoglobulins.