Comparative in vitro activity of newer cephalosporins

To determine the in vitro activity of six new cephalosporins. Determination of minimum inhibitory concentration of new drugs and their comparison with commercially available cephalosporins in clinical use against recent clinical isolates. King Faisal Specialist Hospital and Research Centre, Riyadh [KFSH and RC], Saudi Arabia. 897 bacteria recently isolated from clinical specimens of patients at KFSH and RC. Cefepime, cefpirome, GR 691 53 and Ro 09-1428 were the most active agents against Enterobacteriaceae and Aeromonas hydrophila, inhibiting >90% of them at