ABSTRACT
Asthma is a chronic inflammatory disorder of the airways, which is associated with excessive airway narrowing in response to stimuli that have little or no effect on healthy subjects. Airway hyper-responsiveness with a short duration of asthma is coupled with airway inflammation which may or may not be associated with lung impairment
Objectives: To study correlation of asthma duration with total anti oxidant capacity and lung function parameters
Design: Cross sectional study
Period: June 2013 to Dec 2013
Setting: Baqai Medical University and Hospital
Methodology: A total of 92 known and diagnosed cases of asthma meeting the inclusion criteria were recruited in the study. The subjects included both male and female with age ranging from 16-70 years. Portable handheld electronic Spirometer was used for performing spirometry. FRAP assay was done to measure TAC according to the method of Benzie and Strai
Results: The mean age of patients [n-92] was 34.88 +/- 12.14 SD. The mean duration of asthma was 11.57 +/- 11.30 SD years. Mean value of TAC was found to be 11.46 +/- 4.34SD. Mean FEVI was 1.90 +/- 0.82SD, mean FVC was 2.17 +/- 0.88 SD, mean PEFR was 247.8 +/- 122.7 SD and mean FEV[1]/FVC was 86.21 +/- 16.58 SD. Paired sample t - test was applied to compare the spirometric values which were found highly significant. Pearson correlation was applied and showed negative but insignificant correlation of asthma duration with patients' FEV[1], FEV[1]/FVC and PEFR as well as insignificant correlation with other spirometric parameters and TAC
Conclusion: Our study showed that duration of asthma has no significant correlation with lung function parameters and antioxidant capacity
ABSTRACT
Objectives: to evaluate patients of Chronic Obstructive Pulmonary Diseases [COPD] by spirometry in adult rural population of Karachi
Patients and methods: 53 patients of COPD were subjected to spirometry when they presented with dyspnea in Emergency / Out Patient Department of Fatima hospital. Forced Vital Capacity [FVC], Forced Expiratory Volume in first second [FEY 1] , Peak expiratory flow rate [PEFR] and Percentage ratio [FEY 1 /FVC] were recorded. The variables were compared with control group comprising healthy individuals
Results: 25 out of 53 patients were female between the ages of 16-70 years with mean age 46.24 +/- 5.56 and 28 males between the ages of 16-70 years with mean age 39.5+/- 5:43 were included in the study. FVC ranged between 0.61 to 3.0L with mean 1.80+/- 0.84 SD in patients and 1.85 to 5.67L with mean 3.22 +/- 1.03 SD in control group [p<0.05]. FEVl ranged between 0.4L to 3.82L with mean 1.22:t0.75SD in patients and 1.81L to 4.03L with mean 2.85+/- 0.65SD in control group [p<0.5]. PEFR ranged between 0.55 L/min with mean 2.99+/- 0,81SD in control group [p<0.01]. FEV1/FVC ranged between 23 to 98% with mean 66+/- 18.0lSD in patients and 70 to 99% with mean 88+/- 9.70SD in control group
Conclusion: pulmonary function testing is a useful objective parameter in the evaluation and progress of COPD patients