ABSTRACT
The aim of study is to investigate central and peripheral analgesic effects of methanolic extract of dry ripe fruit of Aegle marmelos Linn. Corea [Am. Cr] by two methods, tail flick test and acetic acid induced writhing test at 100, 250 and 500mg/kg doses in animal models. Analgesic activity against tail flick test revealed that Am. Cr induced significant increase in latency period in dose dependent manner i.e. 65.38% at 100mg/kg, 395.37% at 250mg/kg [p<0.01] and 459.25% at 500mg/kg [p<0.01] body weight at 1hr after drug delivery while at 2hr effect decreased i.e. 61.53% at 100mg/kg, 161.11% [p<0.01] at 250mg/kg and 165.74% [p<0.01] at 500mg/kg but interestingly again there is an elongation in latency period at 3hr i.e. 106.15% at 100mg/kg dose, 251.85% [p<0.01] at 250mg/kg and 293.51% [p<0.05] at 500mg/kg respectively. The standard drug Diclofenac sodium at the dose of 5mg/kg continuously increased the latency period but less significantly as compared to the test substance i.e. 79.43%, 113.08% and 222.42% [p<0.05] respectively. Acetic acid induced writhing test produced highest significant activity at the dose of 100mg/kg i.e. 89.83% [p<0.01] as compared to Diclofenic sodium [standard drug] at a dose of 5mg/kg body weight i.e 63.63% [p<0.01]. It is concluded that dry ripe fruit of A. marmelos possesses significant dual analgesic activities i.e. central and peripheral