Study of the toxic effects of cypermethrin in experimental animals

This study focuses on the toxic effects of a commercially available pesticide, cypermethrin [CM], on animals. This pesticide was administered in the form of aerosol spray through a nebulizer. The study was performed in four different groups and a constant dose of the pesticide was administered once, twice, thrice and four times a day to the respective group for a period of 30 days. The animals were then dissected to study the pesticide effects on different organs. The organs were preserved in 10% formalin. The tissues were processed by basic histopathological method and the slides were prepared for observation. The results were recorded on a performa and were quantified by a unique scoring system. It is concluded that the injurious effects to the mentioned organs were dose and frequency dependent

Histopathological spectrum of gastric biopsies in a tertiary care hospital

This study was carried out to determine the histopathological spectrum of gastric lesions at a tertiary care hospital. A retrospective study. This study was conducted at Dr. Tahir Laboratory from Gastroenterology unit of Hamdard University Hospital Karachi from July 2009 to August 2012. The gastric mucosal biopsies of 280 patients received at Dr. Tahir Laboratory from Gastroenterology unit of Hamdard University Hospital Karachi. A slight higher frequency of gastric disease seen in females with age range of 17 years to 78 years was observed. The clinical presentations mostly seen were abdominal pain, dyspepsia, vomiting, diarrhea, decreased appetite and weight loss. The histopathology revealed chronic active gastritis [H Pylori positive and negative] followed by malignant gastric ulcer. A number of biopsies were unremarkable histologically. The more prevalent lesions in this series were chronic active gastritis. H. pylori associated gastritis was seen in majority of the patients. Thus gastric biopsy is an essential tool for diagnosis and confirmation of clinically suspected cases

Frequency of transitional cell carcinoma in local suburban population of Karachi

To determine the clinicopathological characteristics and frequency of different pathological lesions, particularly Transitional Cell Carcinoma in urinary bladder biopsies, this study was conducted in histopathology section of tertiary care hospitals [Jinnah and Civil hospital] filtering the suburban population of Karachi during August 2001 to July 2005. All patients who visited the Urology. Out Patient Department and presented with haematuria, dysuria etc. were included. Cystoscopy and bladder biopsies were performed. The biopsies were preserved in 10% formalin. Gross examination was done and embedded in paraffin. Light microscopy technique was used for diagnosis. Out of 43 patients, 31 [72.09%] were males and 12 [27.90%] were females. The spectrum of pathological lesions included inflammations, dysplasia and tumours. Transitional cell carcinoma was the most common tumour seen in this study; [93.33%] cases. The peak age of incidence was between 41-68 years