ABSTRACT
Salicyl hydroxamic acid [SHAM] has been found to prevent and treat urinary stones caused by urea splitting hacteria. The present work aims at delineation of its acute toxicity in rats and dogs and its organotropic toxic potential in rats. The obtained results showed that in rats, the oral LD50 of SHAM was 5.0 [3.74 - 7.20] g/kg, while the i.p. LD50 was 0.60 [0.44 - 0.82] g/kg. Administration of 1800 mg.i.p. in dogs resulted in reversible allergic-like skin reactions. The 90 days oral toxicity study of 200 and 500 mg/kg in rats resulted in increased body weight and fluctuations in blood glucose, in addition to hepatic, renal, splenic, and cardiac toxicological and biochemical reactions. Subacute exposure to SHAM in rats has resulted in significant changes in brain amino acid neurotransmitters and an immunosuppressant effect on serum IgG. The obtained results rate are to be utilized for planning of the full preclinical toxicological evaluations