ABSTRACT
Hot flashes are common and discomfortable signs of menopause that present with blazing sweatiness, sense of hotness, tachycardia and agitation. Hot flashes cause disturbances in daily activity and quality of night sleep. In spite of the effect of Hormone Replacement Therapy [HRT] on hot flashes, nowadays, there are diverse opinions about HRT and the reason is that it has chronic complications. In addition, the acceptance of HRT by Iranian women is very low. Study of numerous texts has shown that isofliavone in soybean is a phytoestrogen that could be effective in control of hot flashes. The purpose of the study is to examine the changes in time periods of hot flashes in response to consumption of 74 mg Isoflavone/day present in 60 grams soybeans in menopausal women. This study was a clinical trial with before and after design that included 31 postmenopausal women. The participants were assessed with respect to daily hot flashes at baseline and after one, two and three months of intervention. Participants consumed daily 60 grams soybeans for 3 months. Blood samples were taken at the start and end of intervention for determining levels of gonadotropins and estradiol. Data was analyzed by SPSS software. There was a decrease in time period of hot flashes from baseline of 5.88 +/- 2.61 to 3.45 +/- 1.82 after one month, 2.73 +/- 1.57 after two months and 2.16 +/- 1.48 after three months of consumption of soybeans [P<0.001]. There was decrease in levels of FSH, LH and estradiol after 3 months, but this decrease was not significant, except in the case of estradiol. In line with various studies proposing the use of soybeans in the form of concentrate, drink or capsule, this study suggests that consumption of soybeans [60 gr daily] as snacks may be a safe and effective method for controlling hot flashes in postmenopausal women