Evaluation of developmental delay in infants who came in for 6th month vaccination in Isfahan city health centers

Development delay in one of the most common causes of conferring the pediatric neurologist. The main part of neurological growth and development occur in the first two years especially in the first 6 months of life. Metabolic or skeletal diseases are important causes of developmental delay. Early diagnosis of deviance from the normal diagram of development in lower ages is important. Specific ages and stages questionnaires [ASQ] for 6 months was completed in the health centers of 800 infants conferring for their vaccination in Isfahan and the retest was performed at 24 months of age by ASQ and then these two questionnaires were compared. 10.5% of the infants were delayed in at least one domain. At 24 months, 38.4% of them remained delayed; 21.1% in one domain, 9.6% in two domains, 3.8% in four domains and 3.8% in five domains. Of the children who had problem in communication, 20%; in gross motor, 25%; in fine motor, 20%; and in problem solving, 30% remained delayed. In the personal social domain, none of the delayed children at 6 months remained delayed at 24 months. ASQ is feasible, inexpensive, easy to use and was appreciated by the parents. It can be used as a screening test for detection of developmental delay in lower ages, but its results must be followed by other standard tests or diagnostic tools

Comparing the effect of intravenous midazolam with rectal sodium valproate in controlling of children wit refractory sttus epilepticus

Refractory status epilepticus usually defined as a seizure lasting at least 60 minutes which is uncontrollable by Diazepam, Phenytoin, or Phenobarbital. The aim of this study was to compare the effect of interavenous Midazolam and rectal Sodium valproate in controlling refractory status epilepticus. In this case-control study; 76 children with [mean age of 37 +/- 20 months] with refractory status epilepticus were randomly divided into two groups to receive IV Midazolam and rectal Sodium Valproate. The effect of the two drugs were compared in control of seizure during first 20 minutes of treatment. In 84.2 percent of children treated with IV Midazolam, the seizure was under control within 4.5 +/- 0.5 minutes, while in 63 percent of those receiving Sodium Valproate, the seizure was completely controlled within 16.5 +/- 0.8 minutes [P<0.00001]. The IV Midazolam was more effective than Sodium valproate, but the latter can be used in hospitals or pediatric emergency wards without ICU for controlling of refractory status epilepticus