Endocrinal and ventilatory changes during pneumoperitoneum for laparoscopic cholecystectomy

In this study, the effects of pneumoperitoneum on thirty patients undergoing laparoscopic cholecystectomy were studied to evaluate the ventilatory changes in O2 saturation and end tidal CO2, as well as the endocrinal changes in the stress hormones, namely adrenaline, nor- adrenaline, cortisol and vasopressin. The O2 saturation and end tidal CO2 significantly decreased with the onset of insufflation of CO2 and resumed the normal levels 30 minutes after exsufflation plasma levels of adrenaline, nor-adrenaline, and cortisol showed a marked steady increase throughout the procedure even after exsufflation. The serum vasopressin level showed a highly significant increase after 30 minutes of CO2 insufflation