ABSTRACT
Periodontitis has remarkably similar pathobiology to Rheumatoid Arthritis [RA]. In both these diseases, progression consists of continuing presence of high levels of proinflammatory cytokines. Further more, low levels of Tissue Inhibitors of Metalloproteinases [TIMP] and high levels of Matrix Metalloproteinases [MMP], and PGE-2 secreted by macrophages, fibroblast and other resident and migrating inflammatory cells characterize the active stage of both diseases. This submitted work depicts an evidence based report of a female patient with rheumatoid arthritis and aggressive periodontitis
Subject(s)
Humans , Female , Periodontitis/physiopathology , Periodontitis/etiology , Periodontitis/diagnosis , Arthritis, Rheumatoid , Cytokines , Metalloproteases , Tissue Inhibitor of Metalloproteinase-1 , Tissue Inhibitor of Metalloproteinase-2 , Tissue Inhibitor of Metalloproteinase-3 , Blood Sedimentation , Rheumatoid Factor , C-Reactive ProteinABSTRACT
An interesting case of Papillon-Lefevre Syndrome with persistent thickening, flaking and scaling of the skin of palms and soles associated with recurrently swollen and friable gums since the age of 4 has been presented. Papillon-Lefeure Syndrome is an extremely rare genodematosis inherited as an autosomal recessive trait that is mainly ascertained by dentists because of the severe periodontitis that afflicts patients. This is an interesting case report, which presents the typical features of PLS