Neutrophil chemotactic defect in 60 patients with rickets

Neutrophil mobility in 60 patients with vitamin D-deficient rickets is studied, and the patients are followed after therapy by 600,000 units vitamin D. 28 of 60 patients [46%], had low chemotaxis for neutrophils before vitamin D injection [migration], and 36 of 60 [60%] had low random mobility. The results showed a significant improvement after vitamin D therapy; furthermore, the level of calcium and phosphorus reached normal levels after treatment of the patients as well. We have previously studied neutrophil mobility in 10 patients with rickets. This report serves to complement our previous preliminary report