ABSTRACT
Adiponectin is a novel collagen-like protein synthesized by white adipose tissue. Its level is decreased in obesity, type 2 diabetes and insulin resistant states. It is increased in chronic renal failure. It has anti-inflammatory and antiatherogenic properties. To evaluate the levels of adiponectin in uraemic patients with and without diabetes and to correlate adiponectin level and some cardiovascular risk factors. The study included 100 subjects, 20 of them were healthy subjects and served as control group [group I], and 40 uraemic non diabetic patients [group II], 20 of them without CVC [group hA] and the other 20 patients with CVC [group JIB], and 40 uraemic diabetic patients [group III], 20 of them without CVC [group lIlA] and the other 20 patients with CVC [group IIIB]. All patients were subjected to complete clinical examination including determination of MABP, BMI, R,routine laboratory investigations,[fasting serum glucose,fasting serum insulin, lipid profile, cholesterol,TG, LDL-C, HDL-C], Insulin resistance by HOMA-IR. Serum level of adiponectin was determined by ELISA. There was significant increase in serum adiponectin level in all uraemic patients [group II and group III] when compared to control [group I] at p<0.01 Serum adiponectin level was significantly decreased in uraemic diabetic patients [group III] when compared to uraemic non-diabetic patients [group II] at p<0.01. Patients with cardiovascular complications whether uraemic non diabetic [group IIB] or uraemic diabetic [group IIIB] had a significant decrease in serum adiponectin level when compared to patients without cardiovascular complications [group IIA and group IIIA] at p<0.01. Serum adiponectin has a significant positive correlation with HDL-C and a significant negative correlation with MABP, BMI, serum insulin, HOMA-IR, LDL-C,TG and cholesterol in all patients. Adiponectin level in uraemic patients whether diabetic or non diabetic may be a good indicator of cardiovascular disease risk