ABSTRACT
To investigate the effects of first and second doses of measles vaccine on immunity to measles among infants in Sana'a city,. A total of 518 infants, aged 2-24 months were enrolled. Of these 376 infants were unvaccinated and were either under the age of vaccination or had already passed the age of vaccination [age 2 to 12 months], 71 infants who were given the first dose and 71 infants who were given two doses of measles vaccine. Serum samples were tested for measles specific IgG. Two hundred and seven out of 376 [55.1%] unvaccinated infants were seronegative for measles antibodies. With increasing age, the rates of seronegativity increased and the mean antibody levels among seropositive infants decreased. In the unvaccinated cohort [n=129] who aged 9-12 months [the age at which all infants are due for vaccination], 109 [84.5%] were seronegative. Compared to unvaccinated infants 56 of 71 [78.9%] who were given the first dose of vaccine seroconverted [p<0.0001] developing a significantly higher mean antibody level [p<0.001]. However, 65 of 71 [91.5%] who had received the second vaccine dose seroconverted [p
ABSTRACT
To determine the prevalence of rubella antibodies and age of exposure to rubella among Yemeni schoolgirls, we studied the sera samples of 323 female students [age range 11-21 years; mean age 16.26 +/- 1.89 years] drawn from three schools in Sana'a. All samples were screened for rubella IgG antibodies using enzyme linked immunosorbent assay and, if negative, for IgM in order to exclude the possibility of recent exposure. Of 323 sera, 296 [91.64%] were positive for rubella IgG. All IgG negative sera were also IgM negative. Comparable antibody prevalence was observed in all age groups. The prevalence of rubella IgG among Yemeni schoolgirls is high, with most becoming immune between the ages of 11 and 21 years. Although the age of exposure seems to be 13 years, further investigation is needed to confirm this.
Subject(s)
Humans , Female , Prevalence , Antibodies, Viral , Schools , Immunoglobulin G , Immunoglobulin MABSTRACT
To determine the prevalence of rubella antibodies and age of exposure to rubella among Yemeni schoolgirls, we studied the sera samples of 323 female students [age range 11-21 years; mean age 16.26 +/- 1.89 years] drawn from three schools in Sana'a. All samples were screened for rubella IgG antibodies using enzyme linked immunosorbent assay and, if negative, for IgM in order to exclude the possibility of recent exposure. Of 323 sera, 296 [91.64%] were positive for rubella IgG. All IgG negative sera were also IgM negative. Comparable antibody prevalence was observed in all age groups. The prevalence of rubella IgG among Yemeni schoolgirls is high, with most becoming immune between the ages of 11 and 21 years. Although the age of exposure seems to be