Urinary fibronectin in bladder cancer: is it a reliable tumor marker?

Twenty eight patients with bladder cancer and 21 with different benign urological diseases were included. Healthy persons [15] were tested as a control group. A complete history, general and local examinations, routine investigations as well as urinary fibronectin assay were done using an ELISA technique. Radiodiagnostic studies and cystoscopic examination; and biopsy taking; were then performed. The marker showed a mean value of 260 microgm/L in cases of bladder cancer 96.19 microgm/L in benign urological diseases, and 88.5 microgm/L in control group. It had a 75% sensitivity, 58.8% specificity, and 86.4% overall accuracy.The marker has good diagnostic and fair prognostic abilities