Two Cases of Early Medical Abortion for Patients with Huge Myoma Uteri / 대한주산의학회잡지

No abstract available.

A Case of Paget's Disease of the Vulva / 대한부인종양콜포스코피학회잡지

Extramammary Pagets disease(EMPD) of the vulva is an uncommon neoplasm which accounting for 2.5% of all vulvar malignancies and 0.02% of all female cancer. Several hundred cases have been reported worldwide since the first description by sir James Paget in 1874, It generally affects postrnenopausal age poup and presents high rate of recurrence but the precise incidence remines unclear, Although Paget's disease of the breast and the vulva are histologically similar, their histogenesis and biological behavior are considered to be significantly different and EMPD has gcnerally perceived rnore benign compared to that of the breast. Four histologic forms of vulvar EMPD have been recognized and treated vulvar EMPD in according to the 4 histologic classification. The high rate of recurtence disease remains a challenge for optimal management. Recently we experienced a case of Paget's disease of the vulva, diagnosed as an intraepithelial Pagets disease preoperatively and underwent radical vulvectomy and superiomedial thigh(SMT) flap, and present with a brief review of literature.

The Diagnosis and Treatment in 46 Cases with Microinvasive Carcinoma of the Cervix Uteri / 대한부인종양콜포스코피학회잡지

OBJECTIVE: To review recurrence and prognosis of microivasive squamous cell carcinoma of the cervix that are associated with depth of invasion, pathologic finding and management(conservative or radical treatment) STUDY DESIGN: We conducted retrospective study in order to evaluate the results of therapeutic approaches in 46 patients with microinvasive cervical cancer from Jan 1987 to Oct 1996. RESULT: The mean age of patients was 44.6+ 8.86 years. Only one woman was nullipara, and the mean parity was 2.8, Overall diagnostic accuracy of pap smear and punch biopsy were 54.3% and 79.4%. As the depth of invasion was deeper, the diagnostic accuracy of punch biopsy increased(p<0.05), The confluence pattern and lymphovascular space involvement were observed in 39.1% and 4.9%. The confluence pattern was observed with statistical significant in advanced depth of stromal invasion. In the surgical management, vaginal hysterectomy was done in 28 patients, conization(l patient), total abdominal hysterectomy(8 patients) and radical hysterectomy with pelvic lymph node dissection(9 patients) was done, no positive node was in 104 pelvic lymph node dissected. Though all cone margin was free and all endocervical curettage was negative, residual lesion(2 patients) was present in the hysterectomy after conization, The median follow-up period was 64 months. There was no recurrence in all cases and 5 years survival rate was 100% CONCLUSION: We suggest that microinvasive carcinoma of the cervix may be the disease of good prognosis and no recurrence, and less radical therapy for the patients with microinvasive carcinoma may be sufficient.

A Study on the Possibility of Reducing Corneal Haze with Topical Application of Human Amniotic Fluid in the Wounds Induced by Excimer Laser Keratectomy in Rabbits

Scarless wound healing with minimal inflammation obscured in the fetal skin rpay be due to the fact that amniotic fluid contains factors that may modulate the wound healing process. To examine this possibility, We examined the effect of topical application of human amniotic fluid on the healing of rabbit corneal wounds induced by excimer laser stromal ablation. The right eye received undiluted human amniotic fluid(AF) drops(13th week gestational age) and the left eye received the BSS as a control five times a day for one month. Epithelial healing completed within three days. The wound healing rate was not significant in the early phase but was significant in the late phase(p<0.05). Keratometric regression was significantly less in human amniotic fluid treated(AF group) eyes than BSS treated(control group) eyes. Corneal opacity was significantly less in AF group than control group at one and three months after laser ablation using Scheimpflug camera photography and MacDonald-Schadock class ification(p<0.05). Morphological examination revealed convoluted basement membrane, discontinued hemidesmosome and increased number of activated keratocytes in BSS-treated eyes. These results indicate that corneal scarring(haze) can be reduced by topical application of human amniotic fluid. We speculate that amniotic fluid may contain factors that can facilitate the restoration of fetal environment for wound healing by inhibiting fibroblast activation, thus preventing scar formation.

Biometric analysis of anterior segments of the eye with Scheimpflug Camera according to the type of cataract

We measured the lens thickness and anterior chamber depth on 214 eyes (162 cataract eyes, 52 normal control eyes) using the EAS-1000 Scheimpflug camera. And the results was compared with measurement of A-scan ultrasonography in 49 cataract eyes. The thickness of cataract lens, especially in anterior subcapsular opacities in over 61 years old was significantly thin rather than control lens (p0.05). Lens thickness was increased with age by an annual rate of 0.0l5mm in monnal eyes (p

The Effect of Topical Perfluorophenanthrene on Corneal Neovascularization in the Rats

The effect of topical perfluorophenanthrene on corneal neovascularization was studied at chemically induced corneal burn on the rats. A central corneal burn was produced with 10% NaOH. Right eye was treated with perfluorophenanthrene and gentamicin eye drops four times a day for five days, the left with balanced salt solution and gentamicin eye drops as control. After five days treatment the rats were sacrified, and the tissue slide were prepared for microscopIc examination. Using slide projector the tissue slide were projected and magnified on the screen. The number of corneal new vessels, the distance of new vessel from the limbus, and the degree of increased corneal thickness were calculated in both groups. As the result there were no statistical difference between two groups. Analysis using ANOVA program showed the fact that statistically significant correlationship between the degree of corneal thickness and the number of the new vessels and the distance from the limbus were found. The result could confirm the mechanism of corneal neovascularization that disarrangement of the compact corneal tissue could allow the formation of the new vessels.