ABSTRACT
Anorectal manometry is widely used to evaluate anorectal function. Few reports have described complications resulting from this procedure. A 47-year-old male underwent preoperative chemoradiotherapy and a low anterior resection for rectal cancer. The patient underwent anorectal manometry at postoperative 8 months. A rectal perforation was diagnosed shortly thereafter. The patient was initially managed conservatively using percutaneous drainage and parenteral antibiotics and then discharged on day 60 after the event. One month later, a colo-cutaneous fistula and expanding abdominal fasciitis developed. The patient underwent surgical exploration, drainage, resection of the rectum including the fistula, and redo-coloanal anastomosis with a diverting ileostomy. The patient discharged without complications on postoperative day 25. Anorectal manometry should be performed with particular care in patients who have undergone radiotherapy and anastomosis at the rectum.
Subject(s)
Humans , Male , Middle Aged , Anti-Bacterial Agents , Chemoradiotherapy , Drainage , Fasciitis , Fistula , Ileostomy , Manometry , Rectal Neoplasms , RectumABSTRACT
It is well known that the number of Streptococcus mutans is closely related with dental caries activity. In this study, the capability of glucan production and the glucosyltransferase (gtf) gene expression were examined in the saliva and plaque samples from caries-active and caries-free children. Bacterial cells from each sample were estimated by viable cell count on selective media. The capability of glucan production was determined by measuring the amount of glucan synthesized on orthodontic wires in a medium inoculated with S. mutans isolates from both groups. The mRNA expression for the gtfB and gtfD genes was examined by Fluorescent In Situ Hybridization (FISH). In accordance with previous reports, the numbers of mutans streptococci (MS) and Lactobacilli were higher in caries-active saliva and plaque than in caries-free samples. S. mutans isolated from caries-active samples produced a large amount of glucan, whereas S. mutans from caries-free samples produced little glucan on the orthodontic wires. Finally, the expression of the gtfB and gtfD genes in caries-active plaques was higher than in caries-free plaques. The results suggest that the glucan production and the gtf gene expression as well as the level of MS and lactobacilli should be higher in the samples of caries-active children than those of caries-free children.
Subject(s)
Child , Humans , Cell Count , Dental Caries , Gene Expression , In Situ Hybridization, Fluorescence , Orthodontic Wires , RNA, Messenger , Saliva , Streptococcus mutansABSTRACT
A few cases of femoral neuropathy that were developed after renal transplantation have been reported in western literature. The possible causes of this neuropahty that discussed in recent studies are compression of nerve by self-retaining retractor during operation, ischemia of femoral nerve by iliac muscle hematoma etc. We experienced one case of femoral nerve neuropathy after right iliac fossa renal transplantation that developed at first postoperative day without definitive etiology in all study. It was improved symptomatically after 2 weeks of postoperative day, so we reported this case with brief review of the literatures.
Subject(s)
Femoral Nerve , Femoral Neuropathy , Hematoma , Ischemia , Kidney TransplantationABSTRACT
PURPOSE: Topoisomerase II-alpha is a key enzyme in DNA replication and a molecular target for many anti-cancer drugs. The C-erbB-2 oncogene (HER-2/neu) is the most frequently amplified oncogene in breast cancer. Because of the physical proximity of c-erbB-2 and topoisomerase II-alpha, co-amplification of the c-erbB-2 and topoisomerase II-alpha may occur. To investigate the clinical significance of the topoisomerase II-alpha and c-erbB-2, the correlation between topoisomerase II-alpha and c-erbB-2 was examined by immunohistochemical staining in 43 invasive ductal breast carcinomas and its relationship with other prognostic factors. METHODS: Topoisomerase II-alpha and c-erbB-2 expression was studied immunohistochemically using sections of formalin fixed, paraffin-embedded tumor specimens from 43 invasive ductal breast carcinomas. The correlation between topoisomerase II-alpha and c-erbB-2 expression, and its relationship with the clinicopathological factors such as the tumor size, lymph node metastasis, TNM stage, histological grade, nuclear grade, estrogen receptors and progesteron receptors was investigated. RESULTS: C-erbB-2 was expressed in 9 (20.9%) out of the 43 infiltrating ductal carcinoma cases. Among the prognostic factors, the tumor size, lymph node metastasis, tumor stage, nuclear grade, status of progesteron receptors and estrogen receptors did not significantly correlated with c-erbB-2 expression. The tumor size, lymph node metastasis, tumor stage, histological grade, and the absence of estrogen receptors displayed a significant relationship with the increase in the topoisomerase-alpha index. However, the topoisomerase II-alpha index did not correlate with the nuclear grade and the status of progesterone receptors. The topoisomerase II-alpha index was slightly higher in the c-erbB-2 positive expression cases compared to c-erbB-2 negative expression cases but this increase was not significant (P=0.503). CONCLUSION: These results suggest that topoisomerase II-alpha may play some role as a prognostic factor, but further investigation is needed.
Subject(s)
Breast Neoplasms , Breast , Carcinoma, Ductal , DNA Replication , Formaldehyde , Lymph Nodes , Neoplasm Metastasis , Oncogenes , Receptors, Estrogen , Receptors, ProgesteroneABSTRACT
PURPOSE: Topoisomerase II-alpha is a key enzyme in DNA replication and a molecular target for many anti-cancer drugs. The C-erbB-2 oncogene (HER-2/neu) is the most frequently amplified oncogene in breast cancer. Because of the physical proximity of c-erbB-2 and topoisomerase II-alpha, co-amplification of the c-erbB-2 and topoisomerase II-alpha may occur. To investigate the clinical significance of the topoisomerase II-alpha and c-erbB-2, the correlation between topoisomerase II-alpha and c-erbB-2 was examined by immunohistochemical staining in 43 invasive ductal breast carcinomas and its relationship with other prognostic factors. METHODS: Topoisomerase II-alpha and c-erbB-2 expression was studied immunohistochemically using sections of formalin fixed, paraffin-embedded tumor specimens from 43 invasive ductal breast carcinomas. The correlation between topoisomerase II-alpha and c-erbB-2 expression, and its relationship with the clinicopathological factors such as the tumor size, lymph node metastasis, TNM stage, histological grade, nuclear grade, estrogen receptors and progesteron receptors was investigated. RESULTS: C-erbB-2 was expressed in 9 (20.9%) out of the 43 infiltrating ductal carcinoma cases. Among the prognostic factors, the tumor size, lymph node metastasis, tumor stage, nuclear grade, status of progesteron receptors and estrogen receptors did not significantly correlated with c-erbB-2 expression. The tumor size, lymph node metastasis, tumor stage, histological grade, and the absence of estrogen receptors displayed a significant relationship with the increase in the topoisomerase-alpha index. However, the topoisomerase II-alpha index did not correlate with the nuclear grade and the status of progesterone receptors. The topoisomerase II-alpha index was slightly higher in the c-erbB-2 positive expression cases compared to c-erbB-2 negative expression cases but this increase was not significant (P=0.503). CONCLUSION: These results suggest that topoisomerase II-alpha may play some role as a prognostic factor, but further investigation is needed.
Subject(s)
Breast Neoplasms , Breast , Carcinoma, Ductal , DNA Replication , Formaldehyde , Lymph Nodes , Neoplasm Metastasis , Oncogenes , Receptors, Estrogen , Receptors, ProgesteroneABSTRACT
Six cases of juvenile diabetes mellitus who were admitted Busan National University Hospital from Jan., 1976 to Dec., 1979 were observed. The result were summarized as follows; 1) The mean age of onset was 11 & male to female ratio was 2 to 1 with male preponder ance. One half cases were occrred during spring. Two had family history of diabetes inclu ding one case of diabetic sibling. 2) Polyuria and polydipsia were noted in all cases as initial symptoms and symptoms of polyphagia(4), weight loss(4), weakness(3), enuresis(2) and altered consciousness(2) were noted in order of frequency. More rapid onset, more severe clinical features were observed. Associated illness were noted 4 cases of infection & 1 case of cataract. Mean blood glucose level was 430mg%, urine sugar above 3+and S.G. of urine was above 1.030. 3) Three cases of ketoacidosis & diabetic coma were occurred on admission. Consciousness cleared in 3 days, and ketonuria disappeared in 2 days after insulin & fluid therapy. 4) Mean duration of admission was 24 days. At discharge, dose of insulin needed was 10 to 50 units/day. Two cases were readmitted due to ketoacidosis and postoperative complication but all cases were not sufficiently followed up.
Subject(s)
Female , Humans , Male , Age of Onset , Blood Glucose , Cataract , Consciousness , Diabetes Mellitus , Diabetic Coma , Fluid Therapy , Insulin , Ketosis , Polydipsia , Polyuria , Postoperative Complications , SiblingsABSTRACT
Clinical observation about 34 infants of gestational diabetic mothers(IGDM) and 4 infants of overt diabetic mothers(IDM) was attempted on the 388 large infants(above 4kg.) among 9,263 neonates, who were delivered at the Ilshin Women's hospital during 19 months from Jan. 1977 to July 1978. Birth characteristics, maternal history and perinatal complications were compared with control group of non-diabetic mothers. The results were summerized as follows : 1. The frequency of large infants was 4.2%. Among the large infants, IGDM were 8.8% and IDM were 1.0%. 2. The mean birth weight of IGM ranging in gestational age from 38 to 44 weeks was 4,240gm. No relationship between gestational age and birth weight was noticed. 3. The clinical features of IGDM were asymptomatic hypoglycemia (14.7%), hyperbilir ubinemia(11.8%), Apgar score below 6 at 1min(8.8%), and cogenital mal-formations(5.9%)in order of frequency. But no remarkable difference was noticed between IGDM and control group. 4. Compared with control group, the incidence of gestational diabetic mothers with toxemia and complicated pregnancy was higher. But no diffenence was found about maternal history and other perinatal problems. 5. Among 4 cases of IDM, two with hyperbilirubinemia, Apgar score below 6 at 1 min. and asymptomatic hypoglycemia and one with congenital malformations were noted. One case expired with respiratory distress syndrome.
Subject(s)
Humans , Infant , Infant, Newborn , Pregnancy , Apgar Score , Birth Weight , Gestational Age , Hyperbilirubinemia , Hypoglycemia , Immunoglobulin M , Incidence , Mothers , Parturition , ToxemiaABSTRACT
Authors present two casas of familial metaphyseal dysplasia which was first described by Pyle as a skeletal disorder affecting the metaphyseal region of tubular bones. The cases reported here bear some resemblance to that of Bawkin and Krida.