Anaphylaxis induced by lysozyme in Green cough

Lysozyme is a small protein composed of 129 amino acids with a molecular weight of 14.3 kD. In human, it is in the eye drop, saliva, nasal secretion, and gastric juice. Because of its bactericidal properties, this protein is used as an additive in various food and drug products. A 34-year-old female patient had visited at emergency room for generalized urticaria, angioedema, and dyspnea a few minutes after taking Green cough capsule which contains lysozyme. Her serum tryptase level measured by florescence enzyme immunoassay was 11 mg/mL. Skin prick tests with Green cough itself, and then with its 10 ingredients including lysozyme chloride showed strong positive reaction to Green cough and lysozyme chloride. Base on her symptoms and the results obtained from high level of serum trypase and skin prick tests, we have concluded her conditions to be an anaphylaxis induced by lysozyme.

Efficacy of Itraconazole Melt-Extrusion Tablet One-week Therapy in Treatment of Hyperkeratotic Type of Tinea Pedis and/or Tinea Manus / 대한피부과학회지

BACKGROUND: Since the bioavailability of itraconazole capsule is influenced by patients gastric acidity, it results in treatment failure due to its low dissolution and subsequent low absorption when administered in fasting. Itraconazole Melt-Extrusion tablet has been lately developed in order to improve its dissolution profile. It is the first clinical study to evaluate the efficacy and safety of itraconazole Melt-Extrusion tablet in Korea. OBJECTIVE: This study was conducted to evaluate the efficacy and safety of itraconazole melt-extrusion tablet 400mg daily for 1 week(pulse therapy) for hyperkeratotic type of tinea pedis and manus. METHODS: A clinical and mycological investigation was made of 812 outpatients with hyperkeratotic type of tinea pedis and/or tinea manus who had visited at 52 general hospitals under the lead of the Korean Dermatological Association from June to December, 1998. Patients confirmed by clinically and microscopically as hyperkeratotic type of tinea pedis and/or tinea manus were administered 2 tablets twice a day for one week and followed up for 8 weeks from the start of the medication. RESULTS: The results were summarized as follows; 1. Clinical symptoms of hyperkeratotic type of tinea pedis and/or tinea mauns were significantly improved at the end of study, week 8(p<0.001). 2. Clinical response rate, defined as more than 50% decrease of the sum of the clinical symptom scores, was 79.3%(512/646). 3. Mycological cure rate, dafined as both culture and KOH negative at week 8, was 78.2%(244 /312). 4. 40(5.5%) patients, of the 727 patients evaluable for drug safety evaluation, were reported to have adverse event. CONCLUSION: Itraconazole Melt-Extrusion tablet 400mg/day for 1 week (pulse therapy) is effective and safe in the treatment of hyperkeratotic type of tinea pedis and/or tinea manus.

Nitric Oxide Synthase Expression and Apoptosis in Psoriasis / 대한피부과학회지

BACKGROUND: Nitric oxide(NO) is generated from L-arginine by NO synthase(NOS). Three types of NOS are currently known:inducible(iNOS), neuronal(nNOS) and endothelial(eNOS). NO has been found to be important in a number of different physiological processes. Of particular relevance to the skin are the roles of NO in vasodilatation, inflammation, immunomodulation and in oxidative damage to cells and tissues. NO exhibits contradictory effects in the regulation of apoptosis. The proapoptotic effects seem to be linked to pathophysiological conditions, where high amounts of NO are produced by iNOS. In contrast, the continuous release of eNOS inhibits apoptosis. Psoriasis is a common chronic skin disease, but the cause of psoriasis is not definitely known until now. OBJECTIVE: To investigate the role of NO in psoriasis pathogenesis, such as inflammatory infiltration, dermal vessels dilatation, apoptosis, we performed this study. METHODS: Ten cases of psoriasis and 5 cases of normal skin for immunohistochemical with antibodies to iNOS, PCNA, bcl-2, p53 and TUNEL stainings, and 5 cases of psoriasis and 2 cases of normal skin for western blot with antibody to iNOS were investigated. RESULTS: The results were summarized as follows.1. Immunohistochemical staining with iNOS showed positive reactions in 9 cases(90 %) of psoriasis, 4 cases among them were strong positive staining, but all cases of normal skin were negative.2. Labelling index of PCNA staining was 24.4+2.5%, 2.4+0.7% in psoriasis, normal skin, respectively.3. All cases of psoriasis and normal skin were negative in p53 staining, but squamous cell carcinoma as positive control was positive.4. Bcl-2 staining showed focal positivity in 5(50%) cases of psoriasis, but diffuse positivity in epidermal basal layer of normal skin.5. TUNEL staining showed positivity in 7(70%) cases of psoriasis, but all of normal skin were negative.6. Western blot with anti-iNOS showed positive 130 kDa band in psoriatic, but not in normal skin tissues. CONCLUSION: The results suggested that NO was considered to play a role in psoriasis pathogenesis, including apoptosis, dermal vessels dilatation and inflammatory infiltration.

The longevity of immunofluorescent antibody in the patientsconfirmed as Tsutsugamushi disease / 감염

No abstract available.

A Case of Spontaneously Healed Infantile Hemangiopericytoma / 대한피부과학회지

Infantile hemangiopericytoma deserves separate consideration from adult form of hemangiopericytoma in that it has a benign clinical behavior and distinct histology. We herein report a case of infantile hemangiopericytoma in a 80-day-old male. He had multiple tender subcutaneous nodules on buttock and lower extremities which disappeared spontaneously in 10 months. Microscopically, well circumscribed multiple tumor nodules were seen in the dermis and subcutis and the nodules were consisted of haphazardly packed cells around endothelium-lined vascular slits. Infantile hemangiopericytoma is usually soliitary and spontaneously healed case has not been reported yet.

A Case of Digital Mucous Cyst Treated by Multiple Puncture Method / 대한피부과학회지

We report a case of digital mucous cyst with longitudinal groovings of the nail distal to the cyst which was treated by multiple puncture method described by other authors. The digital mucous cyst was cured without any sequelae and no recurrence has developed within 2 years. Also the nail groovings returned to normal.

A Study for Skin Protection Effect of Suncreens: II. Comparison of Effectiveness Among the Vehicles / 대한피부과학회지

The sunscreening effect can be varied according to the vehicles. Therefore the purpose of this study is to compare the effect of vehicles(bases) on sun protection in p-aminobenzoic acid, cinnamate and benzophenone sunscreens with same concentration (2.5%), We included ointment (white petrolatum), cream (hydrophilic), milky lotion and alcohol as the sunscreen vehicles. The test results can be summarized as follows: We could not recognize a sunscreening effect of sunscreen vehicles which did not contain sunscreening agent. In the case of p-aminobenzoic acid, the mean sun protection factor was higher in the sequence of cream, milky lotion, alcohol, ointment, each showing 9, 95+/-3.67, 8.09+/-2.56, 5.14+/-1.45, 4.35+/-1.46 respectively. In the case of cinnamate, the mean sun protection factor was higher in the sequence of cream, ointment, milky lotion, alcohol, each showing 6 46+/-1.89, 5.42+/-1.49, 4.82+/-1.84, 4.05+/-1.45 respectively. 4. In the case of benzophenone, the mean sun protection factor was higher in the sequence of cream, alcohol, ointment, milky lotion, each showing 5 .26+/-1.56, 4.94+/-1.24, 4.56+/-1.71, 4.18+/-1.23 respectively.

A Case of Atropie Blanche Accompanied by Cryoglobulinemia / 대한피부과학회지

We report a case of atrophie blanche which was accompanied by cryoglobulinemia. The patient, 17-year-old female, have had recurrent painful ulcerations and ivory-white atrophic scars with telangiectases surrounded by hyperpigmentation. On histological examination, vessel wall thickening and hyalinization of the intima, partial vascular occlusion, vascular proliferation and mild perivascular chronic inflammatory cells infiltration and hemorrhage in the upper dermis were noted. The patient had been treated with dipyridarnol(Persantin) and acetylsalicylic acid hut the lesions had been waxed and waned.

Epoxy Resin Contact Dermatitis / 대한피부과학회지

Epoxy resins,which are irritant and allergen, are now used for surface coatings, electrical insulations, adhesives, and construction industry throughout the world. However, epoxy resin contact dermatitis has not been reported in the Korean literature. We report two cases of epoxy resin contact dermatitis which were occupationally related. They have been in the same work, painting dye and resin mixtures on the glasses for decoration. They showed positive patch test reactions to epoxy resin 1, and their own materials containing resins and accelerators which were proved to be -countinue-

A Case of Lymphomatoid Papulosis Treated with PUVA / 대한피부과학회지

Lymphomatoid papulosis is a disease; clinically benign, histologically malignant. Clinically, it may sirnulate pityriasis lichenoides et varioliformis acuta, but histologically it suggest malignant lympboma due to the presence of polymorphous lymphoid infiltrate consisting of sma11 lymphocytes intermingled with conspicuous large atypical cells. Recently, many autbors consider lymphornatoid papulcsis as a Cutaneous T-cell lymphoma, and malignancy has been reported to develop in some patients. We experienced a case of lyrnphomatoid papulosis in 26-year-old woman and treated with PUVA successfully. PUVA treatment may be proven useful in controlling this disease and it rnay also inhibit the development of malignancy.