Role of tumor necrosis factor-alpha, lipid peroxidation, nitric oxide and cyclic gaunosine monophosphate in lung cancer

Cytokines and lipid peroxidation can participate in the complicated process of carcinogenesis and tumor progression. In the present study, the serum levels of tumor necrosis factor-alpha [TNF-alpha], lipid peroxides [LPO], nitric oxide [NO] and cyclic guanosine monophosphate [cGMP] were measured in 32 patients with lung cancer and in 30 healthy control subjects. The levels of TNF-alpha and cGMP were measured using ELISA and the levels of LPO and NO were measured using colorimetric methods. The levels of TNF-alpha, LPO, NO and cGMP were significantly higher in lung cancer patients than in the control group. In patients with lung cancer, a significant positive correlation was found between LPO and each of TNF-alpha and NO. According to the clinical stage and histological type, the serum levels of TNF-alpha, LPO and NO were significantly elevated in the advanced stage and non small cell lung cancer compared with the limited lung cancer. The serum levels of cGMP were higher in advanced than limited lung cancer. A significant positive correlation between NO and cGMP was found in patients with advanced lung cancer. In conclusion, the elevation of serum levels of TNF-alpha, LPO and NO in patient with lung cancer may have a prognostic value, being associated with a worse prognosis. The NO/cGMP system may play an important role in the advanced lung cancer

Role of endothelin-1 and nitric oxide in regulation of thyroid functions

This work aimed to study the interaction of both endothelin [ET- 1] and nitric oxide together with cholesterol in primary hypothyroidism. The study included 14 female patients suffering from primary hypothyroidism and 19 females as controls matching in age and socioeconomic status. The results revealed that there was significant increase in the levels of three parameters studied in patients suffering from hypothyroidism. Also, there was negative correlation between T3 and T4 with TSH, endothelin-I, cholesterol and NO, while there was positive correlation between ET and both NO and cholesterol for all studied cases

effect of alteration in thyroid functions on the oxidant generation

This study examined the effect of hyper and hypothyroidism on lipid peroxide, superoxide dismutase and total thiol group. Forty-nine subjects were included and divided into three groups: Fourteen patients suffering from hypothyroidism, their mean age +/- SE was 46.07 +/- 1.2 years, sixteen patients suffering from hyperthyroidism, their mean age +/- SE was 34.63 +/- 2.05 years and nineteen normal individuals as a control group, their socioeconomic standard matched the previous two groups. Hypothyroidism tended to diminish lipid peroxidation compared with the control group. On the other hand, hyperthyroidism patients showed significant increase in serum lipid peroxide compared with controls. In addition, superoxide dismutase levels were significantly diminished in two groups. Further investigation after the adjustment of thyroid hormones seems to be essential