case report of pegylated interferon and bronchiolitis oblitrans with organizing pneumonia

A 46-year-old woman presented with progressive dyspnea and cough. She was a known case of chronic hepatitis C [HCV] treated with pegylated [PEG]-interferon. Complete pulmonary studies and biopsy were compatible with bronchiolitis oblitrans with organizing pneumonia [BOOP] secondary to PEGinterferon. She discontinued PEG-interferon and was given a short course of steroids, after which the condition completely resolved. This report has shown that particular attention to possible side effects of PEG-interferon is necessary in the clinical practice.