ABSTRACT
Objective The aim of this study was to conduct a population-based epidemiological investigation among a- dults aged over 15 years in the community of huiyang city in guangdong province.Methods A cohort of 12080 residents aged 15 or over from the community of Huizhou city in Guangdong province were enrolled.Logistic regression analysis was used to analyze the epidemiological characteristics and factors of hypertension based on blood pressure values and de- tailed physical examination records from the subjects.Results 2 030 subjects have been diagnosed as hypertension, which made up 16.80% of the prevalence rate (standardized prevalence 13.38%).Logistic regression analysis showed that certain factors such as smoking,age,BMI,family history of hypertension,and amount of sodium chloride intake have influence on hypertension.Conclusion The prevalence rate of hypertension in the adults in this area was high, while the rates of awareness,treatment and control were low.
ABSTRACT
In strengthening the management and innovation of the practical teaching of c1inical medicine,we have taken the right turning and got a satisfactory result:the quality of the clinical teaching work increasing unceasingly and the hospital developing comprehensively.Strengthening the clinical teaching proves to be one of the effective measures to guarantee the quality of the medical students and promote hospital construction and development.
ABSTRACT
BACKGROUND: Cytochrome C oxidase(CCO) is the terminal enzyme in respiration chain of mitochondrion, and it plays a key role in aerobic metabolism and energy production during the process of oxidative phosphorylation. Recently, it is found that energy production of mitochondrion is closely related to the cellular apoptosis, and the changes of CCO activity is closely related to the neuronal impairment after cerebral ischemia and anoxia.OBJECTIVE: To investigate the protective mechanisn of compound pinggan xifeng decoction on the neuronal impairment in cerebral hemorrhage (CH) according to the mitochondrial energy metabolism and cellular apoptosis in neurons.DESIGN: A randomized and controlled trial based on experimental animals.SETTING: Institute of Integrated Traditional Chinese Medicine and Western Medicine, Xiangya Hospital, and Center of Telemedicine.MATERIALS: The experiment was completed in the animal laboratory(key laboratory of province) of Institute of Combination of Traditional Chinese Medicine and Western Medicine from November 2 to 9 in 2003. A total of 80 healthy male SD rats were selected from Experimental Animal Center of Xiangya School of Medicine, Public Health Ministry.METHODS: CH rat models were induced with collagenase Ⅶ, CCO activity was assayed with histochemistry combined with semi-quantification of gray scale, and the cellular apoptosis was evaluated with Tunel method.MAIN OUTCOME MEASURES: CCO activity of CH rats in lateral hippocampal CA1;lateral cellular apoptosis of CH rats.RESULTS: After 12-hour model establishment, CCO activity in CH group was decreased dramatically compared with that in sham operation group (P＜ 0.01), which was 52.12 ±3.75 and 26.98 ±6.32 respectively in lateral hippocampal CA1. And the cellular apoptosis in CH group was increased notably compared with that in sham operation group(P ＜ 0.01),which was(13.56 ± 1.72)/sight and(4. 32 ± 1.04)/sight respectively.Then the two had deteriorated afterwards. After the treatment with pinggan xifeng decoction, CCO activity can be maintained, and the cellular apoptosis was reduced.CONCLUSION: Neuronal injury was closely related to the decrease of CCO activity and the cellular apoptosis in CH. Pinggan xifeng decoction could maintain CO activity of mitochondrion, improve the cellular aerobic netabolism, and reduce the cellular apoptosis, which might be one of the protective mechanisms for secondary neuronal injury in CH.