ABSTRACT
Objective To explore the risk factors for hepatitis B virus (HBV) intrauterine infection to provide a scientific ev idence for itsprevention.Methods Three hundred and twelve pregnant women of HBsAg positive screened from April 2013 to May 2015 served as the research subjects and were followed up until 6 months after birth.The infantile mothers of HBsAg and/or HBV DNA positive were selected as the intrauterine infection case group,while other mothers served as the control group.The Logistic regression analysis was adopted to analyze the risk factors for intrauterine HBV infection.The questionnaire survey method was used to collect the basic data and time-resolved immunofluorescence assay was used to detect HBsAg.PCR was adopted to measure level of HBV DNA and automatic biochemistry analyzer was used to measure the hepatic functional parameters including ALT,AST,triglyceride and cholesterol.Results The single factor analysis results indicated that HBeAg,HBV DNA,contamination of amniotic fluid and sexual behavior during pregnancy were related to HBV intrauterine infection(P＜0.05).The multiple variate Logistic regression results showed that positive HBeAg(OR=2.76,95 ％ CI=1.19-7.94),positive HBV DNA(OR=9.62,95 ％ CI=2.58-35.33),and sexual behaviors during pregnancy (OR =1.53,95 ％ CI =1.07-6.40) were the risk factors for intrauterine HBV infection.Conclusion Pregnant women with positive HBeAg,positive HBV DNA and sexual behavior during pregnancy may be the high risk factors for neonatal intrauterine HBV infection.
ABSTRACT
Objective To analyze the course of development of chronic fatigue syndrome ( CFS) and its research hotspots and frontiers .Methods We retrieved 3723 CFS-related papers published in the Web of Science databases between 2000 and 2014, and obtained a series of mapping knowledge domains with the help of the CiteSpace Ⅲ.Results By visually analyzing the network of international cooperation , mainstream academic communities , development trends and research hotspots in the field of CFS ,the classical literature was quickly decided on and reviewed so that research frontier and development trends were accurately defined .Conclusion Our analysis shows that the academic communities in the field of CFS are mainly located in the United States ,England and other Western countries .Research hotspots shifted from case characters to influence factors ,mechanisms and therapeutic methods .Currently,research frontiers are the etiological theory of pathogen infection and the pathophysiological mechanisms of similar chronic diseases .