ABSTRACT
A persistencia, em alguns individuos, de anticorpos especificos IgM anti-Toxoplasma gondii por varios meses, apos a fase aguda da infeccao, tem complicado a interpretacao dos testes sorologicos para a toxoplasmose. Varios trabalhos tem enfatizado o valor da deteccao de anticorpos especificos IgA anti-T. gondii para o diagnostico da toxoplasmose aguda. No presente trabalho, sao apresentados os resultados da pesquisa de anticorpos especificos das classes IgM e IgA anti-T. gondii em amostras de soros de 12 pacientes, obtidas em diferentes intervalos de tempo, apos o inicio das manifestacoes clinicas da infeccao. Os anticorpos IgM foram detectados pelo teste de imunofluorescencia indireta (IFI)...
Subject(s)
Humans , Autoantibodies/immunology , Immunologic Tests , Toxoplasmosis/diagnosis , Enzyme-Linked Immunosorbent Assay , Fluorescent Antibody Technique, Indirect , Immunoenzyme Techniques , Immunoglobulin A/immunology , Immunoglobulin M/immunology , Signs and Symptoms , Serologic Tests/methods , Toxoplasma/immunology , Toxoplasmosis/transmissionABSTRACT
Total serum IgE, and Strongyloides-specific IgG and IgA antibodies were studied in 27 patients with parasitologically proven strongyloidiasis. Clinical manifestations in this case series were investigated by a retrospective study of the patient's records. Total serum IgE levels were elevated (greater than 250 IU/ml) in 59 of the patients (mean concentration = 1364 IU/ml). Parasite-specific IgG and IgA antibodies were detected by ELISA in the serum of 23 (85.2) and 21 (77.8) patients, respectively. Elevated serum IgE and clinical manifestations were not useful indexes of the presence of strongyloidiasis. On the other hand, our results support the view that serologic tests, particularly ELISA for detecting Strongyloides-specific IgG antibodies, can be usefully exploited for diagnostic purposes in strongyloidiasis.