ABSTRACT
A Classificacao Internacional de Doencas, decima revisao, definiu as mortes maternas decorrentes de anestesia como mortes por causa direta. A gestante com hipertensao arterial grave e um...
Subject(s)
Humans , Female , Hypertension/complications , Maternal Mortality , Pregnancy Complications , AnesthesiaABSTRACT
A hipertensao arterial cronica (HAC) possui grande prevalencia em todo mundo e uma das complicacoes mais comuns durante a gestacao. Um diagnostico preciso da hipertensao arterial permite um tratamento adequado e assim diminuir a morbiletalidade materna e perinatal. O trabalho analisa os diagnosticos clinicos HAC e HAC com doenca hipertensiva especifica da gestacao superajuntada a luz da histopatologia renal, procurando identificar parametros clinicos e laboratoriais que permitissem diferenciar os dois diagnosticos. Analisamos retrospectivamente 96 pacientes cujo resultado histopatologico da biopsia renal pos-parto foram...
Subject(s)
HypertensionABSTRACT
A pre-eclampsia e uma sindrome com repercussoes maternas e fetais, caracterizada por vasoespasmo, ativacao do sistema de coagulacao e alteracoes nos sistemas humorais relacionados ao controle da volemia e da pressao arterial. O estresse oxidativo e a resposta inflamatoria sistemica podem ser tambem importantes na fisiopatologia da sindrome. Nesse trabalho sao abordados os aspectos fisiopatologicos mais recentemente descritos para a...
Subject(s)
Humans , Female , Pregnancy , Pre-Eclampsia/physiopathology , Pregnancy Complications, Cardiovascular , Systemic Inflammatory Response Syndrome/complications , Pre-Eclampsia/immunologyABSTRACT
A hemolise microangiopatica e a lesao hepatica que ocorre nas gestantes com pre-eclampsia/eclampsia continua ainda sendo motivo de controversias, pricipalmente no que se refere a fatores predisponentes, sintomatologia, evolucao natural e conduta...
Subject(s)
Humans , Female , Hypertension , Pre-Eclampsia/complications , Pregnancy, High-Risk , Acute Kidney Injury/pathology , Hyperbilirubinemia , Pre-Eclampsia , Retrospective Studies , Risk FactorsABSTRACT
A correlacao entre estresse e pre-eclampsia foi revisada, avaliada e discutida neste artigo.A pre-eclampsia nao tem ainda etiologia completamente definida. Varios fatores de risco para pre-eclampsia foram identificados e varios mecanismos fisiopatologicos foram descritos...
Subject(s)
Humans , Female , Pregnancy Complications/epidemiology , Pre-Eclampsia/physiopathology , Stress, Physiological/etiology , Hypertension , Pre-Eclampsia/epidemiology , Pre-Eclampsia/etiology , Risk FactorsABSTRACT
CONTEXT: The exact mechanism involved in changes in blood pressure and peripheral vascular resistance during pregnancy is unknown. OBJECTIVE:To evaluate the importance of endothelium-derivated relaxing factor (EDRF) and its main component, nitric oxide, in blood pressure and vascular reactivity in pregnant rats. DESIGN: Clinical trial in experimentation animals. SETTING: University laboratory of Pharmacology. SAMPLE: Female Wistar rats with normal blood pressure, weight (152 to 227 grams) and age (90 to 116 days). INTERVENTION: The rats were divided in to four groups: pregnant rats treated with L-NAME (13 rats); pregnant control rats (8 rats); virgin rats treated with L-NAME (10 rats); virgin control rats (12 rats). The vascular preparations and caudal blood pressure were obtained at the end of pregnancy, or after the administration of L-NAME in virgin rats. MAIN MEASUREMENTS: The caudal blood pressure and the vascular response to acetylcholine in pre-contracted aortic rings, both with and without endothelium, and the effect of nitric oxide inhibition, Nw-L-nitro-arginine methyl-ester (L-NAME), in pregnant and virgin rats. The L-NAME was administered in the drinking water over a 10-day period. RESULTS: The blood pressure decreased in pregnancy. Aortic rings of pregnant rats were more sensitive to acetylcholine than those of virgin rats. After L-NAME treatment, the blood pressure increased and relaxation was blocked in both groups. The fetal-placental unit weight of the L-NAME group was lower than that of the control group. CONCLUSION: Acetylcholine-induced vasorelaxation sensitivity was greater in pregnant rats and that blood pressure increased after L-NAME administration while the acetylcholine-induced vasorelaxation response was blocked.