ABSTRACT
To evaluate the efficacy and safety of tap water iontophoresis [TWI] for the treatment of palmoplantar hyperhidrosis in our local setting. Thirteen patients of idiopathic palmoplantar hyperhidrosis were enrolled in the study from the Department of Dermatology, Lahore Medical and Dental College/Ghurki Hospital and Skin Clinic, Gulberg, Lahore from May 2009 to August 2012. Two patients dropped out, and the study was completed by eleven patients. The patients were treated with TWI three times a week for six weeks and followed up at twelve weeks. Each session lasted for 20 minutes, with the polarity being reversed after 10 minutes. The results were assessed by the hyperhidrosis disease severity index, improvement of sweating on a scale of one to four and the starch-iodine test. Any adverse events were noted. All the patients responded well to the treatment with minimal discomfort. Tap water iontophoresis is a safe, effective, inexpensive and affordable treatment modality for palmoplantar hyperhidrosis. It improves quality of life significantly during treatment.
Subject(s)
Humans , Male , Female , Hyperhidrosis/drug therapy , Treatment Outcome , WaterABSTRACT
To assess the efficacy of itraconazole pulse therapy in disto-lateral subungual onychomycosis. Design: Quasi interventional study. Place and Duration of Study: The study was conducted at the Department of Dermatology, KEMC/Mayo Hospital, Lahore, during the period from 1996-1998. Subjects and Sixty-seven patients, ages ranging from 19 to 55 years, with disto-lateral subungual onychomycosis were enrolled in the study period. Therapy was started with short pulse doses of itraconazole 200 mg twice daily for one week followed by a medicine-free interval of three weeks. Pulses were administered for two consecutive months in fingernail and three months for toenail onychomycosis. Patients were followed upto six months for fingernail onychomycosis and nine months for toenail onychomycosis. Out of 67 cases, there were 62 evaluable patients. Trichophyton rubrum was the most common pathogen, isolated in 42 [67.8%] followed by Candida in 11 [17.8%], T. violaceum in 5 [8%], T. interdigitale in 3 [4.8%] and Epidermophyton floccosum in one [1.6%]. Fingernails were affected in 46 cases whereas 16 had toenail infection. Clinical cure in finger and toenail onychomycosis was seen in 41 [89%] and 13 [81.2%] patients, respectively while mycological cure in 43 [93.5%] and 14 [87.5%] patients, respectively with itraconazole pulse therapy. Itraconazole was found to be effective, well-tolerated and safe therapy for disto-lateral subungual onychomycosis
Subject(s)
Humans , Male , Female , Onychomycosis/drug therapy , Pulse Therapy, Drug , Itraconazole , Foot Dermatoses/microbiology , Hand Dermatoses/microbiology , Antifungal Agents , Drug Administration Schedule , Prospective StudiesABSTRACT
An eleven-year old patient of Proteus syndrome is described. She had asymmetrical hypertrophy of limbs, macrodactyly, port-wine stain, lymphangioma circumscriptum, epidermal verrucous nevus, subcutaneous masses, cerebriform hyperplasia of the sole and digital exostoses