1.
Article
in English
| IMSEAR
| ID: sea-21298
ABSTRACT
The mutagenic potential of phenytoin (PHT) was studied using the sister chromatid exchange (SCE) assay. Twenty nine PHT treated epileptics, 32 untreated and 32 normal healthy controls were analysed. Similar SCE frequencies were observed in untreated patients and patients on PHT monotherapy. Both groups had significantly increased SCE frequency as compared to controls. No positive correlation of SCE frequency with sex and duration of therapy was observed. The results of the present study suggest the role of the disease condition in inducing genetic damage as assessed by increased SCE frequencies.
Subject(s)
Adolescent , Adult , Epilepsy/drug therapy , Female , Humans , Male , Mutagenicity Tests , Phenytoin/adverse effects , Sister Chromatid Exchange/drug effects
2.
J Indian Med Assoc
;
1983 Dec; 81(11-12): 208-9
Article
in English
| IMSEAR
| ID: sea-102616
Subject(s)
Humans , Kidney Calices , Kidney Diseases , Kidney Pelvis , Male , Middle Aged , Rupture, Spontaneous
3.
J Indian Med Assoc
;
1983 Jul 1-16; 81(1-2): 15-6
Article
in English
| IMSEAR
| ID: sea-96168
4.
J Indian Med Assoc
;
1980 Oct; 75(8): 166-7
Article
in English
| IMSEAR
| ID: sea-96532