ABSTRACT
Rabbits were intraperitoneally injected various doses [0, 2, 4 and 6 g/kg body weight] of Monosodium glutamate [MSC] in a 50% solution of deionised water. Blood was drawn an hour after the injection to analyse serum elecyrolytes viz. Sodium, Potassium, Calcium, Magnesium and Chloride. It was indicated that MSG in all doses causes an increase in the level of serum sodium, calcium and magnesium while serum potassium and chloride levels decreased. Therefore, it is concluded that our study is consistent with prior research done upon dose - specific MSG neurotoxicity, hyperosmolarity and blood - brain - barrier dysfunction in laboratory animals. The ingestion of MSG may affect the serum electrolyte balance and influence the interpretation of clinical data of the subjects