ABSTRACT
<p><b>OBJECTIVE</b>To investigate the central auditory processing function in children with functional articulation disorders (FAD), and possible causes of FAD.</p><p><b>METHODS</b>Twenty-seven children with FAD were selected as the case group and 50 age-matched normal children were selected as the control group. The two groups were compared with respect to the following factors: percentage of individuals with a positive history of language development disorder, and the form, peak latency and peak amplitude of mismatch negativity (MMN) on auditory event-related potentials.</p><p><b>RESULTS</b>Compared with the control group, the case group had a significantly higher percentage of individuals with a positive history of language development disorder (70% vs 8%; P<0.01), a significantly prolonged peak latency of MMN (209 ± 31 ms vs 175 ± 32 ms; P<0.01), and an insignificantly lower peak amplitude of MMN (P>0.05).</p><p><b>CONCLUSIONS</b>Prolonged central auditory processing may be one of the causes of FAD in children.</p>
Subject(s)
Child , Child, Preschool , Female , Humans , Male , Articulation Disorders , Evoked Potentials, Auditory , PhysiologyABSTRACT
<p><b>OBJECTIVE</b>To study the conditions and parameters of purifying 2,3,5,4'-tetrahydroxy-stilbene-2-O-beta-D-glycoside from Polygonum multiflori.</p><p><b>METHOD</b>Absorption capacity of four resins for 2,3,5,4'-tetrahydroxy-stilbene-2-O-beta-D-glycoside was compared. With the adsorption ability as indexes, the process of absorbing and purifying 2,3,5,4'-tetrahydroxy-stilbene-2-O-beta-D-glycoside from P. multiflori with S-8 macroporous resin absorbent was selected by orthogonal design.</p><p><b>RESULT</b>The S-8 resin was the best of the four resins. The optimum process condition was 50% ethanol as eluting solvent, the flow rate at 1.5 mL x min(-1), pH at 7-8, and the solution concentration at 0.2 g x mL(-1). The absorption capacity by this process was 36.89 mg x g(-1).</p><p><b>CONCLUSION</b>The process is simple and convenient and the regeneration of resin is easy, so this method of purification is advisable.</p>