ABSTRACT
Introduction: The prevalence and histopathological type ofgastric polyp vary between populations. In the recent pastaggressive treatment of Helicobacter pylori (H. pylori) and theexcessive use of proton pump inhibitors (PPIs) have alteredthe prevalence of specific types of gastric polyp. This studywas designed to evaluate the prevalence and histopathologybackground of gastric mucosa in cases with fundic glandpolyps (FGP).Material and Methods: The medical record of patients whounderwent esophagogastroduodenoscopy in 2 centers inNorthern India from 2011-2018 were reviewed.Results: The prevalence of gastric polyps was 5%, of which900 (50%) were fundic gland polyps (FGP). Mean age ofpresentation was 51.42 years, 70% were located in fundus/corpus, 62% had dyspepsia, chronic inactive gastritis (CIG)was present in 60%, 95% were multiple and 27% were morethan 1cm in size.Conclusions: As a result of anti - H. pylori treatment and theexcessive use of PPIs, FGP are most common in Northern India.CIG, H. pylori gastritis and Intestinal metaplasia were seen ingastric histology of the cases. These results are interesting andprovide new perspective to look for pathogenesis of gastricpolyps.
ABSTRACT
Introduction: Various regimens have been used for H-pylorieradication. Sequential therapy is an alternative to classicaltriple therapy. This study was designed for evaluatingthe efficacy of levofloxacin based sequential therapyvs clarithromycin based sequential therapy in H-pylorieradication.Material and methods: It is a randomized clinical trial. Twohundred H. Pylori infected patients diagnosed by rapid ureasetest (RUT) on UGI endoscopy were randomly divided intotwo groups A and B. Group B Levofloxacin based sequentialregimen and group A clarithromycin based sequential regimen.H-pylori eradication status was evaluated with rapid ureasetest on UGI endoscopy 6 weeks after completion of sequentialtherapy.Results: As per protocol, eradication rates for group B and Awere 86% and 81% respectively. Eradication rate for H-pyloriis greater with levofloxacin based sequential therapy ascompared to that of clarithromycin based sequential therapybut it is not statistically significant p >0.05.Conclusion: Levofloxacin based sequential therapy has highereradication rate than clarithromycin based sequential therapy.Although not statistically significant in our study, levofloxacinbased sequential therapy could be better alternative forthe treatment of H-pylori in areas with high clarithromycinresistance.