ABSTRACT
Postoperative intraperitoneal adhesion formation is a common clinical occurrence, a major cause of morbidity and an occasional cause of mortality. This study was designed to evaluate the role of alcoholic extract of Piper longum in the prevention of Acetic Acid induced intraperitoneal adhesions in rats. Intraperitoneal injections of Piper longum extract, 10 mg/100 mg b.w. [Test Group], showed a potent activity comparable to Betamethasone 1 ml/100 gm b.w. [Standard Group] and grades of adhesions were confined to 0, 1 and 2 in these two groups as compared to grades 3 and 4 in rats in which Normal Saline was used [as control]. Mononuclear cell infiltration, fibroblastic proliferation and mesothelial thickening were mostly mild to moderate in the test group and the standard group as compared to the control group in which it was severe. This study suggests that alcoholic extract of Piper longum has a potent activity in the prevention of Acetic Acid induced intraperitoneal adhesions in rats
ABSTRACT
Gleason's tumour grade has been accepted as a benchmark protocol in qualifying prostate cancer on histology. Since cyto-evaluation of suspected prostatic malignancy is being increasingly accepted, we have attempted a correlation between cytologic smear pattern categories and Gleason's grade, accorded on cytologic and histologic material and obtained from the same patient, simultaneously in 60 patients. The cytologic smears were classified as 1 well differentiated, corresponding to combined Gleason score 2-4, II moderately differentiated, Gleason 5-7, and III poorly differentiated, corresponding to Gleason 8-10. An overall concordance of 89% was observed between grading on cytologic and histologic material. The incidence of metastases and progression of clinical stage were also found to be clearly influenced by the cytologically accorded grade